| pubmed-article:10950947 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10950947 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10950947 | lifeskim:mentions | umls-concept:C1720947 | lld:lifeskim |
| pubmed-article:10950947 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10950947 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:10950947 | lifeskim:mentions | umls-concept:C1427590 | lld:lifeskim |
| pubmed-article:10950947 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:10950947 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:10950947 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:10950947 | pubmed:issue | 46 | lld:pubmed |
| pubmed-article:10950947 | pubmed:dateCreated | 2000-12-29 | lld:pubmed |
| pubmed-article:10950947 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10950947 | pubmed:abstractText | Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and promotes cytochrome c-dependent caspase activation by neutralizing inhibitor of apoptosis proteins (IAPs). We provide evidence that Smac/DIABLO functions at the levels of both the Apaf-1-caspase-9 apoptosome and effector caspases. The N terminus of Smac/DIABLO is absolutely required for its ability to interact with the baculovirus IAP repeat (BIR3) of XIAP and to promote cytochrome c-dependent caspase activation. However, it is less critical for its ability to interact with BIR1/BIR2 of XIAP and to promote the activity of the effector caspases. Consistent with the ability of Smac/DIABLO to function at the level of the effector caspases, expression of a cytosolic Smac/DIABLO in Type II cells allowed TRAIL to bypass Bcl-xL inhibition of death receptor-induced apoptosis. Combined, these data suggest that Smac/DIABLO plays a critical role in neutralizing IAP inhibition of the effector caspases in the death receptor pathway of Type II cells. | lld:pubmed |
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| pubmed-article:10950947 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10950947 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10950947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10950947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10950947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10950947 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10950947 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10950947 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10950947 | pubmed:author | pubmed-author:DattaPP | lld:pubmed |
| pubmed-article:10950947 | pubmed:author | pubmed-author:HuangZZ | lld:pubmed |
| pubmed-article:10950947 | pubmed:author | pubmed-author:AlnemriE SES | lld:pubmed |
| pubmed-article:10950947 | pubmed:author | pubmed-author:FanX JXJ | lld:pubmed |
| pubmed-article:10950947 | pubmed:author | pubmed-author:Fernandes-Aln... | lld:pubmed |
| pubmed-article:10950947 | pubmed:author | pubmed-author:SrinivasulaS... | lld:pubmed |
| pubmed-article:10950947 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10950947 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:10950947 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10950947 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10950947 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10950947 | pubmed:pagination | 36152-7 | lld:pubmed |
| pubmed-article:10950947 | pubmed:dateRevised | 2008-5-14 | lld:pubmed |
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| pubmed-article:10950947 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10950947 | pubmed:articleTitle | Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway. | lld:pubmed |
| pubmed-article:10950947 | pubmed:affiliation | Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. | lld:pubmed |
| pubmed-article:10950947 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10950947 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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