| pubmed-article:10950788 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10950788 | lifeskim:mentions | umls-concept:C0008151 | lld:lifeskim |
| pubmed-article:10950788 | lifeskim:mentions | umls-concept:C0205064 | lld:lifeskim |
| pubmed-article:10950788 | lifeskim:mentions | umls-concept:C0546816 | lld:lifeskim |
| pubmed-article:10950788 | lifeskim:mentions | umls-concept:C1285573 | lld:lifeskim |
| pubmed-article:10950788 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:10950788 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:10950788 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10950788 | pubmed:dateCreated | 2000-11-3 | lld:pubmed |
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| pubmed-article:10950788 | pubmed:abstractText | Recurrent Chlamydia trachomatis infections are common among sexually active women. Although recurrences with a new chlamydial serovar indicate reinfection, same-serovar recurrences may be due to persistence. Because persistence has important implications for pathogenesis and patient management, we identified 552 women with >3 recurrences over 2 years. Among these, 130 women (24%) had same-serovar recurrences; 58 (45%) were C class serovars (odds ratio, 2.4; 95% confidence interval, 1.7-3.5; P<.0001). Forty-five isolates from 7 women with 3-10 repeated, same-serovar infections over 2-5 years were studied. As determined by omp1 genotyping, 4 women had identical genotypes at each recurrence; 2 women had 1 or 2 amino acid changes following treatment, and one was persistently infected with a unique genotype, Ja. Many intervening culture-negative samples were positive when tested by ligase chain reaction, which suggests persistence. These data demonstrate that cervical infections with C class serovars can persist for years and may have specific biologic properties that allow for modulation of the major outer membrane protein in response to immune selection. | lld:pubmed |
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| pubmed-article:10950788 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10950788 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10950788 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10950788 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10950788 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10950788 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:10950788 | pubmed:author | pubmed-author:StammW EWE | lld:pubmed |
| pubmed-article:10950788 | pubmed:author | pubmed-author:DeanDD | lld:pubmed |
| pubmed-article:10950788 | pubmed:author | pubmed-author:SuchlandR JRJ | lld:pubmed |
| pubmed-article:10950788 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10950788 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:10950788 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10950788 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10950788 | pubmed:pagination | 909-16 | lld:pubmed |
| pubmed-article:10950788 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10950788 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10950788 | pubmed:articleTitle | Evidence for long-term cervical persistence of Chlamydia trachomatis by omp1 genotyping. | lld:pubmed |
| pubmed-article:10950788 | pubmed:affiliation | Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA. ddean@chori.org | lld:pubmed |
| pubmed-article:10950788 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10950788 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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