| pubmed-article:10945636 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0376623 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0242643 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0032405 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0596130 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:10945636 | lifeskim:mentions | umls-concept:C1704222 | lld:lifeskim |
| pubmed-article:10945636 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:10945636 | pubmed:dateCreated | 2000-8-31 | lld:pubmed |
| pubmed-article:10945636 | pubmed:abstractText | Mouse embryo fibroblasts lacking poly(ADP-ribose) polymerase (PARP)-1 express a barely detectable level of wild-type (wt) p53 protein. Doxorubicin at concentrations activating wt p53 in normal mouse embryo fibroblasts failed to induce it in mutant cells. wt p53 was only activated in response to a 10-fold higher doxorubicin dose. Treatment with higher doxorubicin concentrations was cytotoxic for normal but not for PARP-1 -/- cells. The latter was also resistant to other anticancer agents. The increased resistance of mutant cells to drugs resembled a unique phenomenon known as multidrug resistance (MDR). Interestingly, the MDR gene product P-glycoprotein was clearly up-regulated in PARP-1-deficient cells as compared with normal counterparts. Pretreatment with verapamil reversed the MDR phenotype. | lld:pubmed |
| pubmed-article:10945636 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10945636 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10945636 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10945636 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10945636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10945636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10945636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10945636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10945636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10945636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10945636 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10945636 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10945636 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10945636 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:10945636 | pubmed:author | pubmed-author:Wesierska-Gad... | lld:pubmed |
| pubmed-article:10945636 | pubmed:author | pubmed-author:HercegZZ | lld:pubmed |
| pubmed-article:10945636 | pubmed:author | pubmed-author:WurzerGG | lld:pubmed |
| pubmed-article:10945636 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10945636 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10945636 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:10945636 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10945636 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10945636 | pubmed:pagination | 4238-44 | lld:pubmed |
| pubmed-article:10945636 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:meshHeading | pubmed-meshheading:10945636... | lld:pubmed |
| pubmed-article:10945636 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10945636 | pubmed:articleTitle | Increased resistance to anticancer therapy of mouse cells lacking the poly(ADP-ribose) polymerase attributable to up-regulation of the multidrug resistance gene product P-glycoprotein. | lld:pubmed |
| pubmed-article:10945636 | pubmed:affiliation | Institute of Cancer Research, University of Vienna, Austria. | lld:pubmed |
| pubmed-article:10945636 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10945636 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10945636 | lld:pubmed |
