Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response.
Source:http://linkedlifedata.com/resource/pubmed/id/10944538
J. Biol. Chem.
2000
Nov
10
275
45
35368-76
