Linked Life Data

10939635

Source:http://linkedlifedata.com/resource/pubmed/id/10939635

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pubmed-article:10939635pubmed:abstractTextIn saponin-skinned muscle fibers from adult rat heart and m. soleus the apparent affinity of the mitochondrial oxidative phosphorylation system for ADP (Km = 200-400 microM) is much lower than in isolated mitochondria (Km = 10-20 microM). This suggests a limited permeability of the outer mitochondrial membrane (OMM) to adenine nucleotides in slow-twitch muscle cells. We have studied the postnatal changes in the affinity of mitochondrial respiration for ADP, in relation to morphological alterations and expression of mitochondrial creatine kinase (mi-CK) in rat heart in vivo. Analysis of respiration of skinned fibers revealed a gradual decrease in the apparent affinity of mitochondria to ADP throughout 6 weeks post partum that indicates the development of mechanism which increasingly limits the access of ADP to mitochondria. The expression of mi-CK started between the 1st and 2nd weeks and reached the adult levels after 6 weeks. This process was associated with increases in creatine-activated respiration and affinity of oxidative phosphorylation to ADP thus reflecting the progressive coupling of mi-CK to adenine nucleotide translocase. Laser confocal microscopy revealed significant changes in rearrangement of mitochondria in cardiac cells: while the mitochondria of variable shape and size appeared to be random-clustered in the cardiomyocytes of 1 day old rat, they formed a fine network between the myofibrils by the age of 3 weeks. These results allow to conclude that in early period of development, i.e. within 2-3 weeks, the diffusion of ADP to mitochondria becomes progressively restricted, that appears to be related to significant structural rearrangements such as formation of the mitochondrial network. Later (after 3 weeks) the control shifts to mi-CK, which by coupling to adenine nucleotide translocase, allows to maximally activate the processes of oxidative phosphorylation despite limited access of ADP through the OMM.lld:pubmed
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pubmed-article:10939635pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:10939635pubmed:articleTitleDevelopmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo.lld:pubmed
pubmed-article:10939635pubmed:affiliationLaboratory of Bioenergetics, Institute of Chemical and Biological Physics, Tallinn, Estonia.lld:pubmed
pubmed-article:10939635pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10939635pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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