| pubmed-article:10938900 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10938900 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:10938900 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10938900 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:10938900 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:10938900 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:10938900 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:10938900 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:10938900 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:10938900 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10938900 | pubmed:dateCreated | 2000-9-19 | lld:pubmed |
| pubmed-article:10938900 | pubmed:abstractText | In human platelets and other non-excitable cell types depletion of the intracellular calcium stores promotes calcium entry across the plasma membrane. Although the mechanism of this store-mediated calcium entry remains uncertain, it has been suggested that a tyrosine phosphorylation step could be involved. In support of this hypothesis various tyrosine kinase inhibitors have been shown to reduce store-mediated calcium entry in platelets, although this inhibition is never complete. Here we investigate the properties of store-mediated calcium entry in human platelets during the time course of its activation. Our data suggest that at least two pathways may contribute to store-mediated calcium entry in these cells. An early component, activated soon after the initiation of Ca2+ store depletion, is insensitive to trivalent cations, SKF 96365 and tyrosine kinase inhibitors. This is followed by a second component which is inhibited by La3+, SKF 96365 and by tyrosine kinase inhibitors. These results suggest a role for tyrosine kinases in generating only the later stages of store-mediated calcium entry in platelets and may explain the incomplete inhibition of this pathway by inhibitors of tyrosine kinases. | lld:pubmed |
| pubmed-article:10938900 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10938900 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938900 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10938900 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10938900 | pubmed:issn | 0953-7104 | lld:pubmed |
| pubmed-article:10938900 | pubmed:author | pubmed-author:SageS OSO | lld:pubmed |
| pubmed-article:10938900 | pubmed:author | pubmed-author:JennerSS | lld:pubmed |
| pubmed-article:10938900 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10938900 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:10938900 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10938900 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10938900 | pubmed:pagination | 215-21 | lld:pubmed |
| pubmed-article:10938900 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
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| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:meshHeading | pubmed-meshheading:10938900... | lld:pubmed |
| pubmed-article:10938900 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10938900 | pubmed:articleTitle | Two pathways for store-mediated calcium entry in human platelets. | lld:pubmed |
| pubmed-article:10938900 | pubmed:affiliation | Department of Physiology, University of Cambridge, UK. sj10014@cus.cam.ac.uk | lld:pubmed |
| pubmed-article:10938900 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10938900 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10938900 | lld:pubmed |
