| pubmed-article:10938276 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10938276 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10938276 | lifeskim:mentions | umls-concept:C0007610 | lld:lifeskim |
| pubmed-article:10938276 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10938276 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10938276 | lifeskim:mentions | umls-concept:C0009219 | lld:lifeskim |
| pubmed-article:10938276 | pubmed:issue | 43 | lld:pubmed |
| pubmed-article:10938276 | pubmed:dateCreated | 2000-11-24 | lld:pubmed |
| pubmed-article:10938276 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938276 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938276 | pubmed:abstractText | Studies to clone a cell-surface DNA-binding protein involved in the binding and internalization of extracellular DNA have led to the isolation of a gene for a membrane-associated nucleic acid-binding protein (MNAB). The full-length cDNA is 4.3 kilobases with an open reading frame of 3576 base pairs encoding a protein of approximately 130 kDa (GenBank accession numbers and ). The MNAB gene is on human chromosome 9 with wide expression in normal tissues and tumor cells. A C3HC4 RING finger and a CCCH zinc finger have been identified in the amino-terminal half of the protein. MNAB bound DNA (K(D) approximately 4 nm) and mutagenesis of a single conserved amino acid in the zinc finger reduced DNA binding by 50%. A potential transmembrane domain exists near the carboxyl terminus. Antibodies against the amino-terminal half of the protein immunoprecipitated a protein of molecular mass approximately 150 kDa and reacted with cell surfaces. The MNAB protein is membrane-associated and primarily localized to the perinuclear space, probably to the endoplasmic reticulum or trans-Golgi network. Characterization of the MNAB protein as a cell-surface DNA-binding protein, critical in binding and internalization of extracellular DNA, awaits confirmation of its localization to cell surfaces. | lld:pubmed |
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| pubmed-article:10938276 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10938276 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10938276 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10938276 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10938276 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10938276 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10938276 | pubmed:author | pubmed-author:BennettR MRM | lld:pubmed |
| pubmed-article:10938276 | pubmed:author | pubmed-author:TanakaTT | lld:pubmed |
| pubmed-article:10938276 | pubmed:author | pubmed-author:DeffebachM... | lld:pubmed |
| pubmed-article:10938276 | pubmed:author | pubmed-author:MerkensL SLS | lld:pubmed |
| pubmed-article:10938276 | pubmed:author | pubmed-author:HefeneiderS... | lld:pubmed |
| pubmed-article:10938276 | pubmed:author | pubmed-author:McCoyS LSL | lld:pubmed |
| pubmed-article:10938276 | pubmed:author | pubmed-author:HeinrichM CMC | lld:pubmed |
| pubmed-article:10938276 | pubmed:author | pubmed-author:SiessD CDC | lld:pubmed |
| pubmed-article:10938276 | pubmed:author | pubmed-author:FreedA CAC | lld:pubmed |
| pubmed-article:10938276 | pubmed:author | pubmed-author:VedderC TCT | lld:pubmed |
| pubmed-article:10938276 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10938276 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:10938276 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10938276 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10938276 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10938276 | pubmed:pagination | 33655-62 | lld:pubmed |
| pubmed-article:10938276 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10938276 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10938276 | pubmed:articleTitle | A human gene coding for a membrane-associated nucleic acid-binding protein. | lld:pubmed |
| pubmed-article:10938276 | pubmed:affiliation | Departments of Immunology, Pulmonology and Hematology, Veterans Affairs Medical Center, Portland, Oregon 97201, USA. | lld:pubmed |
| pubmed-article:10938276 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10938276 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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