| pubmed-article:10933725 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C1527169 | lld:lifeskim |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:10933725 | lifeskim:mentions | umls-concept:C0439603 | lld:lifeskim |
| pubmed-article:10933725 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:10933725 | pubmed:dateCreated | 2000-9-14 | lld:pubmed |
| pubmed-article:10933725 | pubmed:abstractText | Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent host, but remains a major cause of morbidity in immunosuppressed individuals. Using the recently described technique of staining antigen-specific CD8(+) T cells with peptide-HLA tetrameric complexes, we have demonstrated high levels of antigen-specific cells specific for HCMV peptides and show that this may exceed 4% of CD8(+) T cells in immunocompetent donors. Moreover, by staining with tetramers in combination with antibodies to cell surface markers and intracellular cytokines, we demonstrate functional heterogeneity of HCMV-specific populations. A substantial proportion of these are effector cytotoxic T lymphocytes, as demonstrated by their ability to lyse peptide-pulsed targets in "fresh" killing assays. These data suggest that the immune response to HCMV is periodically boosted by a low level of HCMV replication and that sustained immunological surveillance contributes to the maintenance of host-pathogen homeostasis. These observations should improve our understanding of the immunobiology of persistent viral infection. | lld:pubmed |
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| pubmed-article:10933725 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10933725 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10933725 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10933725 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10933725 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10933725 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:10933725 | pubmed:author | pubmed-author:MurphyMM | lld:pubmed |
| pubmed-article:10933725 | pubmed:author | pubmed-author:SmithNN | lld:pubmed |
| pubmed-article:10933725 | pubmed:author | pubmed-author:WillsM RMR | lld:pubmed |
| pubmed-article:10933725 | pubmed:author | pubmed-author:CONER ARA | lld:pubmed |
| pubmed-article:10933725 | pubmed:author | pubmed-author:GillespieG... | lld:pubmed |
| pubmed-article:10933725 | pubmed:author | pubmed-author:O'CallaghanCC | lld:pubmed |
| pubmed-article:10933725 | pubmed:author | pubmed-author:MossP APA | lld:pubmed |
| pubmed-article:10933725 | pubmed:author | pubmed-author:Rowland-Jones... | lld:pubmed |
| pubmed-article:10933725 | pubmed:author | pubmed-author:SissonsPP | lld:pubmed |
| pubmed-article:10933725 | pubmed:author | pubmed-author:AppanAA | lld:pubmed |
| pubmed-article:10933725 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10933725 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:10933725 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10933725 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10933725 | pubmed:pagination | 8140-50 | lld:pubmed |
| pubmed-article:10933725 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10933725 | pubmed:year | 2000 | lld:pubmed |
