| pubmed-article:1092788 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1092788 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:1092788 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:1092788 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1092788 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1092788 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1092788 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1092788 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:1092788 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:1092788 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:1092788 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1092788 | pubmed:dateCreated | 1975-7-18 | lld:pubmed |
| pubmed-article:1092788 | pubmed:abstractText | Spleen cells from C3H/HeJ mice fail to respond with polyclonal antibody synthesis to mitogenic concentrations of lipopolysaccharide (LPS) which are optimal for activating spleen cells from a high-responder strain (B10.5M). This unresponsiveness is selective for LPS, since C3H/HeJ cells respond as normals to another B-cell mitogen, purified protein derivative of tuberculin. Spleen cells from low-responder mice also fail to mount a specific anti-NNP plaque-forming cell (PFC) response, when challenged in vitro by NNP-LPS. However, C3H/HeJ cells develop normal responses to another thymus-independent hapten conjugate, DNP-AECM-Ficoll. C3H/HeJ mice fail to mount a specific anti-LPS antibody response, when challenged in vivo with doses of soluble LPS which are fully immunogenic for the high-responder strain. However, C3H/HeJ mice develop normal direct and indirect PFC responses to LPS, when challenged with a thymus-dependent form of the immunogen. These results are interpreted as indicating as absolute requirement for functional mitogenicity of the antigen, in the induction of specific thymus-independent antibody responses. | lld:pubmed |
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| pubmed-article:1092788 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1092788 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1092788 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1092788 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1092788 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1092788 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:1092788 | pubmed:author | pubmed-author:CoutinhoAA | lld:pubmed |
| pubmed-article:1092788 | pubmed:author | pubmed-author:GronowiczEE | lld:pubmed |
| pubmed-article:1092788 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1092788 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1092788 | pubmed:volume | 141 | lld:pubmed |
| pubmed-article:1092788 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1092788 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1092788 | pubmed:pagination | 753-60 | lld:pubmed |
| pubmed-article:1092788 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1092788 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:1092788 | pubmed:articleTitle | Genetical control of B-cell responses. III. Requirement for functional mitogenicity of the antigen in thymus-independent specific responses. | lld:pubmed |
| pubmed-article:1092788 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1092788 | pubmed:publicationType | Comparative Study | lld:pubmed |
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