Linked Life Data

10919675

Source:http://linkedlifedata.com/resource/pubmed/id/10919675

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10919675rdf:typepubmed:Citationlld:pubmed
pubmed-article:10919675lifeskim:mentionsumls-concept:C0027651lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0025918lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0025921lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0001430lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0021853lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0018270lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0079419lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0002085lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0815327lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0392756lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0439232lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0683598lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C1521828lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C1516451lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C1514623lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0449822lld:lifeskim
pubmed-article:10919675lifeskim:mentionsumls-concept:C0442821lld:lifeskim
pubmed-article:10919675pubmed:issue14lld:pubmed
pubmed-article:10919675pubmed:dateCreated2000-8-24lld:pubmed
pubmed-article:10919675pubmed:abstractTextAltered patterns of the 5-cytosine methylation of genomic DNA are associated with the development of a wide range of human cancers. We have studied the mechanisms and genetic pathways by which a targeted heterozygous deficiency in the murine 5-cytosine DNA methyltransferase gene (Dnmt1(N/+)) diminishes intestinal tumorigenesis in C57BL/6-multiple intestinal neoplasia (Min)/+ mice. We found that Dnmt1(N/+) retards the net growth rate of intestinal adenomas and reduces tumor multiplicity by approximately 50%. This tumor resistance affects the entire intestinal tract and is independent of the status of modifier of Min 1 and p53, two loci that have been found to confer strong resistance to Min-induced neoplasia Interestingly, Dnmt/(N/+) and modifier of Min 1 resistance interact synergistically, together virtually eliminating tumor incidence. This finding may provide an insight into potential combinatorial therapeutic approaches for treating human colon cancer.lld:pubmed
pubmed-article:10919675pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10919675pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10919675pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10919675pubmed:languageenglld:pubmed
pubmed-article:10919675pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10919675pubmed:citationSubsetIMlld:pubmed
pubmed-article:10919675pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10919675pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10919675pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10919675pubmed:statusMEDLINElld:pubmed
pubmed-article:10919675pubmed:monthJullld:pubmed
pubmed-article:10919675pubmed:issn0008-5472lld:pubmed
pubmed-article:10919675pubmed:authorpubmed-author:DoveW FWFlld:pubmed
pubmed-article:10919675pubmed:authorpubmed-author:CormierR TRTlld:pubmed
pubmed-article:10919675pubmed:issnTypePrintlld:pubmed
pubmed-article:10919675pubmed:day15lld:pubmed
pubmed-article:10919675pubmed:volume60lld:pubmed
pubmed-article:10919675pubmed:ownerNLMlld:pubmed
pubmed-article:10919675pubmed:authorsCompleteYlld:pubmed
pubmed-article:10919675pubmed:pagination3965-70lld:pubmed
pubmed-article:10919675pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:meshHeadingpubmed-meshheading:10919675...lld:pubmed
pubmed-article:10919675pubmed:year2000lld:pubmed
pubmed-article:10919675pubmed:articleTitleDnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele.lld:pubmed
pubmed-article:10919675pubmed:affiliationMcArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706, USA.lld:pubmed
pubmed-article:10919675pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10919675pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
entrez-gene:11789entrezgene:pubmedpubmed-article:10919675lld:entrezgene
entrez-gene:13433entrezgene:pubmedpubmed-article:10919675lld:entrezgene
entrez-gene:18780entrezgene:pubmedpubmed-article:10919675lld:entrezgene
entrez-gene:22059entrezgene:pubmedpubmed-article:10919675lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:10919675lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:10919675lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10919675lld:pubmed