| pubmed-article:10913181 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10913181 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
| pubmed-article:10913181 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:10913181 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10913181 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:10913181 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:10913181 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:10913181 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:10913181 | pubmed:dateCreated | 2000-8-28 | lld:pubmed |
| pubmed-article:10913181 | pubmed:abstractText | Using an inducible transcription system which allows the regulated expression of C/EBP isoforms in tissue culture cells, we have found that the ectopic expression of C/EBPalpha, at a level comparable to that found in normal liver tissue, has a pronounced antimitogenic effect in mouse L cells and NIH 3T3 cells. The inhibition of cell division by C/EBPalpha in mouse cells cannot be reversed by simian virus 40 T antigen, by oncogenic ras, or by adenovirus E1a protein. When expressed in thymidine kinase-deficient L cells or 3T3 cells, C/EBPalpha is detected in a protein complex which binds to the E2F binding sites found in the promoters of the genes for E2F-1 and dihydrofolate reductase (DHFR). Bacterially expressed C/EBPalpha has no affinity for these E2F sites, but when recombinant C/EBPalpha is added to nuclear extracts from mouse fibroblasts, a new E2F binding activity appears, which contains the C/EBPalpha protein. Using an E2F-DP1-responsive promoter linked to a reporter gene, it can be shown that C/EBPalpha directly inhibits the induction of this promoter by E2F-DP1 in transient-transfection assays. Furthermore, C/EBPalpha can be shown to inhibit the S-phase induction of the E2F and DHFR promoters in permanent cell lines. These findings delineate a straightforward mechanism for C/EBPalpha-mediated cell growth arrest through repression of E2F-DP-mediated S-phase transcription. | lld:pubmed |
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| pubmed-article:10913181 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10913181 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10913181 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10913181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10913181 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10913181 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10913181 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:10913181 | pubmed:author | pubmed-author:KurtzD TDT | lld:pubmed |
| pubmed-article:10913181 | pubmed:author | pubmed-author:KellyM MMM | lld:pubmed |
| pubmed-article:10913181 | pubmed:author | pubmed-author:SlomianyB ABA | lld:pubmed |
| pubmed-article:10913181 | pubmed:author | pubmed-author:D'ArigoK LKL | lld:pubmed |
| pubmed-article:10913181 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10913181 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:10913181 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10913181 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10913181 | pubmed:pagination | 5986-97 | lld:pubmed |
| pubmed-article:10913181 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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