| pubmed-article:10908724 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10908724 | lifeskim:mentions | umls-concept:C1646870 | lld:lifeskim |
| pubmed-article:10908724 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:10908724 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:10908724 | lifeskim:mentions | umls-concept:C1705920 | lld:lifeskim |
| pubmed-article:10908724 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:10908724 | lifeskim:mentions | umls-concept:C0916529 | lld:lifeskim |
| pubmed-article:10908724 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10908724 | pubmed:dateCreated | 2000-8-18 | lld:pubmed |
| pubmed-article:10908724 | pubmed:abstractText | In a search for new inhibitors of the IFN-gamma mediated signal transduction in HeLa S3 cells using secreted alkaline phosphatase (SEAP) as reporter gene, the novel pyran-dione trichodion was isolated from fermentations of the imperfect fungus Trichosporiella sp. 20-95. The compound inhibits the IFN-gamma mediated expression of the reporter gene with IC(50) values of 21-42 microM (5-10 microgram/ml). The NF-kappaB and AP-1 mediated expression of the reporter gene are inhibited with IC(50) values of 42-84 microM (10-20 microgram/ml) and 21 microM (5 microgram/ml) respectively. Western blotting with COX-2 and NOS II antibodies showed that the expression of both proinflammatory enzymes is almost completely inhibited at 21-42 microM (5-10 microgram/ml) in LPS/IFN-gamma stimulated J774 mouse macrophages. Studies on the mode of action of the compound revealed that the inhibition of the NF-kappaB dependent pathway is due to the stabilization of the IkappaB protein and the inhibition of the IFN-gamma dependent signaling is caused by an inhibition of the phosphorylation of the STAT1alpha transcription factor. | lld:pubmed |
| pubmed-article:10908724 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10908724 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10908724 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10908724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10908724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10908724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10908724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10908724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10908724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10908724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10908724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10908724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10908724 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10908724 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10908724 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:10908724 | pubmed:author | pubmed-author:ErkenEE | lld:pubmed |
| pubmed-article:10908724 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10908724 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10908724 | pubmed:volume | 477 | lld:pubmed |
| pubmed-article:10908724 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10908724 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10908724 | pubmed:pagination | 219-23 | lld:pubmed |
| pubmed-article:10908724 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10908724 | pubmed:meshHeading | pubmed-meshheading:10908724... | lld:pubmed |
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| pubmed-article:10908724 | pubmed:meshHeading | pubmed-meshheading:10908724... | lld:pubmed |
| pubmed-article:10908724 | pubmed:meshHeading | pubmed-meshheading:10908724... | lld:pubmed |
| pubmed-article:10908724 | pubmed:meshHeading | pubmed-meshheading:10908724... | lld:pubmed |
| pubmed-article:10908724 | pubmed:meshHeading | pubmed-meshheading:10908724... | lld:pubmed |
| pubmed-article:10908724 | pubmed:meshHeading | pubmed-meshheading:10908724... | lld:pubmed |
| pubmed-article:10908724 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10908724 | pubmed:articleTitle | Trichodion, a new inhibitor of inflammatory signal transduction pathways from a Trichosporiella species. | lld:pubmed |
| pubmed-article:10908724 | pubmed:affiliation | Institut für Biotechnologie und Wirkstoff-Forschung e.V., Erwin-Schrödinger-Str. 56, D-67663, Kaiserslautern, Germany. erkel@ibwf.uni-kl.de | lld:pubmed |
| pubmed-article:10908724 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10908724 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
