| pubmed-article:10899915 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10899915 | lifeskim:mentions | umls-concept:C0019169 | lld:lifeskim |
| pubmed-article:10899915 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:10899915 | lifeskim:mentions | umls-concept:C0042774 | lld:lifeskim |
| pubmed-article:10899915 | lifeskim:mentions | umls-concept:C0036330 | lld:lifeskim |
| pubmed-article:10899915 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:10899915 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10899915 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10899915 | pubmed:dateCreated | 2000-8-10 | lld:pubmed |
| pubmed-article:10899915 | pubmed:abstractText | Although coinfection of hepatitis B virus (HBV) and Schistosoma mansoni is a frequent event in humans, little is known about the interactions between these two pathogens. S. mansoni infection induces T helper cell type 2 (Th2)-type cytokines in the liver of humans and mice. The intrahepatic induction of nitric oxide (NO) and Th1-type cytokines, such as interferon (IFN)-gamma and IFN-alpha/beta, inhibits HBV replication noncytopathically in the liver of transgenic mice. To examine whether S. mansoni infection and the accompanying induction of Th2-type cytokines could interfere with HBV replication in the liver, HBV transgenic mice were infected with S. mansoni. By 5 wk after infection, HBV replication disappeared concomitant with the intrahepatic induction of NO and Th1-type cytokines, and in the absence of Th2-type cytokines. By 6-8 wk after infection, HBV replication remained undetectable and this was associated with further induction of NO and Th1-type cytokines together with the appearance of Th2-type cytokines. The S. mansoni-dependent antiviral effect was partially blocked by genetically deleting IFN-gamma, although it was unaffected by deletion of IFN-alpha/beta. These results indicate that IFN-gamma (probably via NO) mediates most of this antiviral activity and that Th2-type cytokines do not counteract the antiviral effect of IFN-gamma. Similar events may suppress HBV replication during human S. mansoni infection. | lld:pubmed |
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| pubmed-article:10899915 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10899915 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899915 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10899915 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10899915 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10899915 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:10899915 | pubmed:author | pubmed-author:KochRR | lld:pubmed |
| pubmed-article:10899915 | pubmed:author | pubmed-author:ChisariF VFV | lld:pubmed |
| pubmed-article:10899915 | pubmed:author | pubmed-author:GuidottiL GLG | lld:pubmed |
| pubmed-article:10899915 | pubmed:author | pubmed-author:McClaryHH | lld:pubmed |
| pubmed-article:10899915 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10899915 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:10899915 | pubmed:volume | 192 | lld:pubmed |
| pubmed-article:10899915 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10899915 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10899915 | pubmed:pagination | 289-94 | lld:pubmed |
| pubmed-article:10899915 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10899915 | pubmed:meshHeading | pubmed-meshheading:10899915... | lld:pubmed |
| pubmed-article:10899915 | pubmed:meshHeading | pubmed-meshheading:10899915... | lld:pubmed |
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| pubmed-article:10899915 | pubmed:meshHeading | pubmed-meshheading:10899915... | lld:pubmed |
| pubmed-article:10899915 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10899915 | pubmed:articleTitle | Inhibition of hepatitis B virus replication during schistosoma mansoni infection in transgenic mice. | lld:pubmed |
| pubmed-article:10899915 | pubmed:affiliation | Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA. | lld:pubmed |
| pubmed-article:10899915 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10899915 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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