CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation.
Source:http://linkedlifedata.com/resource/pubmed/id/10899907
J. Exp. Med.
2000
Jul
17
192
2
205-18
