| pubmed-article:10899151 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10899151 | lifeskim:mentions | umls-concept:C1328887 | lld:lifeskim |
| pubmed-article:10899151 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
| pubmed-article:10899151 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10899151 | pubmed:dateCreated | 2000-9-28 | lld:pubmed |
| pubmed-article:10899151 | pubmed:abstractText | The parking strategy is an iterative approach to DNA sequencing. Each iteration consists of sequencing a novel portion of target DNA that does not overlap any previously sequenced region. Subject to the constraint of no overlap, each new region is chosen randomly. A parking strategy is often ideal in the early stages of a project for rapidly generating unique data. As a project progresses, parking becomes progressively more expensive and eventually prohibitive. We present a mathematical model with a generalization to allow for overlaps. This model predicts multiple parameters, including progress, costs, and the distribution of gap sizes left by a parking strategy. The highly fragmented nature of the gaps left after an initial parking strategy may make it difficult to finish a project efficiently. Therefore, in addition to our parking model, we model gap closing by walking. Our gap-closing model is generalizable to many other strategies. Our discussion includes modified parking strategies and hybrids with other strategies. A hybrid parking strategy has been employed for portions of the Human Genome Project. | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10899151 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899151 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10899151 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10899151 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10899151 | pubmed:issn | 1088-9051 | lld:pubmed |
| pubmed-article:10899151 | pubmed:author | pubmed-author:SiegelA FAF | lld:pubmed |
| pubmed-article:10899151 | pubmed:author | pubmed-author:RoachJ CJC | lld:pubmed |
| pubmed-article:10899151 | pubmed:author | pubmed-author:ThorssonVV | lld:pubmed |
| pubmed-article:10899151 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10899151 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:10899151 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10899151 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10899151 | pubmed:pagination | 1020-30 | lld:pubmed |
| pubmed-article:10899151 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10899151 | pubmed:meshHeading | pubmed-meshheading:10899151... | lld:pubmed |
| pubmed-article:10899151 | pubmed:meshHeading | pubmed-meshheading:10899151... | lld:pubmed |
| pubmed-article:10899151 | pubmed:meshHeading | pubmed-meshheading:10899151... | lld:pubmed |
| pubmed-article:10899151 | pubmed:meshHeading | pubmed-meshheading:10899151... | lld:pubmed |
| pubmed-article:10899151 | pubmed:meshHeading | pubmed-meshheading:10899151... | lld:pubmed |
| pubmed-article:10899151 | pubmed:meshHeading | pubmed-meshheading:10899151... | lld:pubmed |
| pubmed-article:10899151 | pubmed:meshHeading | pubmed-meshheading:10899151... | lld:pubmed |
| pubmed-article:10899151 | pubmed:meshHeading | pubmed-meshheading:10899151... | lld:pubmed |
| pubmed-article:10899151 | pubmed:meshHeading | pubmed-meshheading:10899151... | lld:pubmed |
| pubmed-article:10899151 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10899151 | pubmed:articleTitle | Parking strategies for genome sequencing. | lld:pubmed |
| pubmed-article:10899151 | pubmed:affiliation | The Institute for Systems Biology, Seattle, Washington 98105 USA. jroach@systembiology.org | lld:pubmed |
| pubmed-article:10899151 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10899151 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10899151 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10899151 | lld:pubmed |
