| pubmed-article:10899050 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10899050 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:10899050 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:10899050 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:10899050 | lifeskim:mentions | umls-concept:C0205374 | lld:lifeskim |
| pubmed-article:10899050 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10899050 | pubmed:dateCreated | 2000-8-16 | lld:pubmed |
| pubmed-article:10899050 | pubmed:abstractText | A novel transient outward K(+) current that exhibits inward-going rectification (I(to.ir)) was identified in guinea pig atrial and ventricular myocytes. I(to.ir) was insensitive to 4-aminopyridine (4-AP) but was blocked by 200 micromol/l Ba(2+) or removal of external K(+). The zero current potential shifted 51-53 mV/decade change in external K(+). I(to.ir) density was twofold greater in ventricular than in atrial myocytes, and biexponential inactivation occurs in both types of myocytes. At -20 mV, the fast inactivation time constants were 7.7 +/- 1.8 and 6.1 +/- 1.2 ms and the slow inactivation time constants were 85.1 +/- 14.8 and 77.3 +/- 10.4 ms in ventricular and atrial cells, respectively. The midpoints for steady-state inactivation were -36.4 +/- 0.3 and -51.6 +/- 0.4 mV, and recovery from inactivation was rapid near the resting potential (time constants = 7.9 +/- 1.9 and 8.8 +/- 2.1 ms, respectively). I(to.ir) was detected in Na(+)-containing and Na(+)-free solutions and was not blocked by 20 nmol/l saxitoxin. Action potential clamp revealed that I(to.ir) contributed an outward current that activated rapidly on depolarization and inactivated by early phase 2 in both tissues. Although it is well known that 4-AP-sensitive transient outward current is absent in guinea pig, this Ba(2+)-sensitive and 4-AP-insensitive K(+) current has been overlooked. | lld:pubmed |
| pubmed-article:10899050 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899050 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899050 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899050 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10899050 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899050 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10899050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10899050 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10899050 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10899050 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:10899050 | pubmed:author | pubmed-author:YanoJJ | lld:pubmed |
| pubmed-article:10899050 | pubmed:author | pubmed-author:BaumgartenC... | lld:pubmed |
| pubmed-article:10899050 | pubmed:author | pubmed-author:SuhBB | lld:pubmed |
| pubmed-article:10899050 | pubmed:author | pubmed-author:DASRR | lld:pubmed |
| pubmed-article:10899050 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10899050 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:10899050 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10899050 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10899050 | pubmed:pagination | H130-8 | lld:pubmed |
| pubmed-article:10899050 | pubmed:dateRevised | 2008-3-3 | lld:pubmed |
| pubmed-article:10899050 | pubmed:meshHeading | pubmed-meshheading:10899050... | lld:pubmed |
| pubmed-article:10899050 | pubmed:meshHeading | pubmed-meshheading:10899050... | lld:pubmed |
| pubmed-article:10899050 | pubmed:meshHeading | pubmed-meshheading:10899050... | lld:pubmed |
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| pubmed-article:10899050 | pubmed:meshHeading | pubmed-meshheading:10899050... | lld:pubmed |
| pubmed-article:10899050 | pubmed:meshHeading | pubmed-meshheading:10899050... | lld:pubmed |
| pubmed-article:10899050 | pubmed:meshHeading | pubmed-meshheading:10899050... | lld:pubmed |
| pubmed-article:10899050 | pubmed:meshHeading | pubmed-meshheading:10899050... | lld:pubmed |
| pubmed-article:10899050 | pubmed:meshHeading | pubmed-meshheading:10899050... | lld:pubmed |
| pubmed-article:10899050 | pubmed:meshHeading | pubmed-meshheading:10899050... | lld:pubmed |
| pubmed-article:10899050 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10899050 | pubmed:articleTitle | Existence of a transient outward K(+) current in guinea pig cardiac myocytes. | lld:pubmed |
| pubmed-article:10899050 | pubmed:affiliation | Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada H3C 3J7. gli@hsc.vcu.edu | lld:pubmed |
| pubmed-article:10899050 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10899050 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10899050 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10899050 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10899050 | lld:pubmed |
