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pubmed-article:10898340pubmed:abstractTextBisphosphonates currently are the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia, Paget's disease, and osteoporosis. These compounds have high affinity for calcium and therefore target to bone mineral, where they appear to be internalized selectively by bone-resorbing osteoclasts and inhibit osteoclast function.lld:pubmed
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pubmed-article:10898340pubmed:articleTitleCellular and molecular mechanisms of action of bisphosphonates.lld:pubmed
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