| pubmed-article:10896677 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10896677 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:10896677 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:10896677 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10896677 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10896677 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:10896677 | lifeskim:mentions | umls-concept:C0205357 | lld:lifeskim |
| pubmed-article:10896677 | pubmed:issue | 40 | lld:pubmed |
| pubmed-article:10896677 | pubmed:dateCreated | 2000-10-23 | lld:pubmed |
| pubmed-article:10896677 | pubmed:abstractText | Results show that smooth muscle-specific promoters represent novel downstream targets of the winged helix factor hepatocyte nuclear factor-3 homologue 1 (HFH-1). HFH-1 strongly represses telokin promoter activity when overexpressed in A10 vascular smooth muscle cells. HFH-1 was also found to repress transcription of several other smooth muscle-specific promoters, including the SM22alpha promoter. HFH-1 inhibits telokin promoter activity, by binding to a forkhead consensus site located within an AT-rich region of the telokin promoter. The DNA-binding domain alone was sufficient to mediate inhibition, suggesting that binding of HFH-1 blocks the binding of other positive-acting factors. HFH-1 does not disrupt serum response factor binding to an adjacent CArG box within the telokin promoter, implying that HFH-1 must compete with other unidentified trans-activators to mediate repression. The localization of HFH-1 mRNA to the epithelial cell layer of mouse bladder and stomach implicates HFH-1 in repressing telokin expression in epithelial cells. This suggests that cell-specific expression of telokin is likely mediated by both positive-acting factors in smooth muscle cells and negative-acting factors in nonmuscle cell types. We propose a model in which the smooth muscle specificity of the telokin promoter is regulated by interactions between positive- and negative-acting members of the hepatocyte nuclear factor-3/forkhead family of transcription factors. | lld:pubmed |
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| pubmed-article:10896677 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10896677 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10896677 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10896677 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10896677 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10896677 | pubmed:author | pubmed-author:SmithA FAF | lld:pubmed |
| pubmed-article:10896677 | pubmed:author | pubmed-author:HerringB PBP | lld:pubmed |
| pubmed-article:10896677 | pubmed:author | pubmed-author:HoggattA MAM | lld:pubmed |
| pubmed-article:10896677 | pubmed:author | pubmed-author:KriegerA SAS | lld:pubmed |
| pubmed-article:10896677 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10896677 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:10896677 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10896677 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10896677 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10896677 | pubmed:pagination | 31162-70 | lld:pubmed |
| pubmed-article:10896677 | pubmed:dateRevised | 2011-11-10 | lld:pubmed |
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| pubmed-article:10896677 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10896677 | pubmed:articleTitle | Hepatocyte nuclear factor-3 homologue 1 (HFH-1) represses transcription of smooth muscle-specific genes. | lld:pubmed |
| pubmed-article:10896677 | pubmed:affiliation | Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA. | lld:pubmed |
| pubmed-article:10896677 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10896677 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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