| pubmed-article:10886789 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10886789 | lifeskim:mentions | umls-concept:C0041296 | lld:lifeskim |
| pubmed-article:10886789 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:10886789 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:10886789 | lifeskim:mentions | umls-concept:C1979963 | lld:lifeskim |
| pubmed-article:10886789 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:10886789 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:10886789 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10886789 | pubmed:dateCreated | 2000-8-3 | lld:pubmed |
| pubmed-article:10886789 | pubmed:abstractText | T cells mediate protection against tuberculosis, but little is known about their role during chemotherapy of patients with active disease. Here we examined the cytokine profile of CD4 T cells before and after four months of chemotherapy in six initial skin test anergic cases. Purified protein derivative (PPD) and 16-kDa antigen-reactive CD4 T-cell clones prior to therapy resided mostly in disease-associated body fluids and were of the Th0 (interferon (IFN)-gamma + interleukin (IL)-4) secreting profile. In contrast, the majority of postchemotherapy CD4 T-cell clones originated from blood and were of the IFN-gamma secreting Th1 type. However, the recognition of several peptides derived from the 16-kDa antigen was not significantly different between the Th1 and Th0 clones. We conclude that chemotherapy shifts CD4 T cells from the affected body fluids to the blood circulation, accompanied by a change from Th0 to Th1 cytokine profile. | lld:pubmed |
| pubmed-article:10886789 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10886789 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10886789 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10886789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10886789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10886789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10886789 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10886789 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10886789 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10886789 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:10886789 | pubmed:author | pubmed-author:SalernoAA | lld:pubmed |
| pubmed-article:10886789 | pubmed:author | pubmed-author:SinghMM | lld:pubmed |
| pubmed-article:10886789 | pubmed:author | pubmed-author:RomanoAA | lld:pubmed |
| pubmed-article:10886789 | pubmed:author | pubmed-author:IvanyiJJ | lld:pubmed |
| pubmed-article:10886789 | pubmed:author | pubmed-author:SantiniDD | lld:pubmed |
| pubmed-article:10886789 | pubmed:author | pubmed-author:TitoneLL | lld:pubmed |
| pubmed-article:10886789 | pubmed:author | pubmed-author:FrisciaGG | lld:pubmed |
| pubmed-article:10886789 | pubmed:author | pubmed-author:DieliFF | lld:pubmed |
| pubmed-article:10886789 | pubmed:author | pubmed-author:SireciGG | lld:pubmed |
| pubmed-article:10886789 | pubmed:author | pubmed-author:Di SanoCC | lld:pubmed |
| pubmed-article:10886789 | pubmed:author | pubmed-author:SpallekRR | lld:pubmed |
| pubmed-article:10886789 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10886789 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:10886789 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10886789 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10886789 | pubmed:pagination | 96-102 | lld:pubmed |
| pubmed-article:10886789 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10886789 | pubmed:meshHeading | pubmed-meshheading:10886789... | lld:pubmed |
| pubmed-article:10886789 | pubmed:meshHeading | pubmed-meshheading:10886789... | lld:pubmed |
| pubmed-article:10886789 | pubmed:meshHeading | pubmed-meshheading:10886789... | lld:pubmed |
| pubmed-article:10886789 | pubmed:meshHeading | pubmed-meshheading:10886789... | lld:pubmed |
| pubmed-article:10886789 | pubmed:meshHeading | pubmed-meshheading:10886789... | lld:pubmed |
| pubmed-article:10886789 | pubmed:meshHeading | pubmed-meshheading:10886789... | lld:pubmed |
| pubmed-article:10886789 | pubmed:meshHeading | pubmed-meshheading:10886789... | lld:pubmed |
| pubmed-article:10886789 | pubmed:meshHeading | pubmed-meshheading:10886789... | lld:pubmed |
| pubmed-article:10886789 | pubmed:meshHeading | pubmed-meshheading:10886789... | lld:pubmed |
| pubmed-article:10886789 | pubmed:meshHeading | pubmed-meshheading:10886789... | lld:pubmed |
| pubmed-article:10886789 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10886789 | pubmed:articleTitle | Change of Th0 to Th1 cell-cytokine profile following tuberculosis chemotherapy. | lld:pubmed |
| pubmed-article:10886789 | pubmed:affiliation | Section of Pathology, Department of Biopathology, University of Palermo, 90134 Palermo, Italy. | lld:pubmed |
| pubmed-article:10886789 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10886789 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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