| pubmed-article:10880530 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10880530 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:10880530 | lifeskim:mentions | umls-concept:C0072402 | lld:lifeskim |
| pubmed-article:10880530 | lifeskim:mentions | umls-concept:C0244989 | lld:lifeskim |
| pubmed-article:10880530 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:10880530 | lifeskim:mentions | umls-concept:C1155055 | lld:lifeskim |
| pubmed-article:10880530 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:10880530 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10880530 | pubmed:dateCreated | 2000-8-15 | lld:pubmed |
| pubmed-article:10880530 | pubmed:abstractText | Glycogen synthase kinase (GSK)-3 is a protein serine/threonine kinase that regulates differentiation and cell fate in a variety of organisms. This study examined the role of GSK-3 in antigen-specific T cell responses. Using resting T cells from P14 T cell receptor (TCR)-transgenic mice (specific for the lymphocytic choriomeningitis virus and H-2D(b)), we demonstrated that GSK-3beta was inactivated by serine phosphorylation after viral peptide-specific stimulation in vitro. To further investigate the role of GSK-3, we have generated a retroviral vector that expresses a constitutively active form of GSK-3beta that has an alanine substitution at the regulatory amino acid, serine 9 (GSK-3betaA9). Retroviral transduction of P14 TCR-transgenic bone marrow stem cells, followed by reconstitution, led to the expression of GSK-3betaA9 in bone marrow chimeric mice. T cells from chimeric mice demonstrate a reduction in proliferation and interleukin (IL)-2 production. In contrast, in vitro assays done in the presence of the GSK-3 inhibitor lithium led to dramatically prolonged T cell proliferation and increased IL-2 production. Furthermore, in the presence of lithium, we show that nuclear factor of activated T cells (NF-AT)c remains in the nucleus after antigen-specific stimulation of T cells. Together, these data demonstrate that GSK-3 negatively regulates the duration of T cell responses. | lld:pubmed |
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| pubmed-article:10880530 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10880530 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10880530 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10880530 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10880530 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10880530 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:10880530 | pubmed:author | pubmed-author:ParsonsMM | lld:pubmed |
| pubmed-article:10880530 | pubmed:author | pubmed-author:JonesR GRG | lld:pubmed |
| pubmed-article:10880530 | pubmed:author | pubmed-author:WoodgettJ RJR | lld:pubmed |
| pubmed-article:10880530 | pubmed:author | pubmed-author:NguyenL TLT | lld:pubmed |
| pubmed-article:10880530 | pubmed:author | pubmed-author:OhtekiTT | lld:pubmed |
| pubmed-article:10880530 | pubmed:author | pubmed-author:OhashiP SPS | lld:pubmed |
| pubmed-article:10880530 | pubmed:author | pubmed-author:ZakarianAA | lld:pubmed |
| pubmed-article:10880530 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10880530 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:10880530 | pubmed:volume | 192 | lld:pubmed |
| pubmed-article:10880530 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10880530 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10880530 | pubmed:pagination | 99-104 | lld:pubmed |
| pubmed-article:10880530 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10880530 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10880530 | pubmed:articleTitle | Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. | lld:pubmed |
| pubmed-article:10880530 | pubmed:affiliation | Ontario Cancer Institute, Department of Medical Biophysics, Toronto, Ontario M5G 2M9, Canada. | lld:pubmed |
| pubmed-article:10880530 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10880530 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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