| pubmed-article:10875615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:10875615 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:10875615 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10875615 | pubmed:dateCreated | 2000-7-25 | lld:pubmed |
| pubmed-article:10875615 | pubmed:abstractText | HIV-specific CD4+ helper T cell responses, particularly to the envelope glycoproteins, are usually weak or absent in the majority of HIV-seropositive individuals. Since antibodies, by their capacity to alter antigen uptake and processing, are known to have modulatory effects on CD4+ T cell responses, we investigated the effect of antibodies produced by HIV-infected individuals on the CD4+ T cell response to HIV-1 gp120. Proliferative responses of gp120-specific CD4+ T cells were inhibited in the presence of either serum immunoglobulin from HIV-infected individuals or human monoclonal antibodies specific for the CD4-binding domain (CD4bd) of gp120. Human monoclonal antibodies to other gp120 epitopes did not have the same effect. The anti-CD4bd antibodies complexed with gp120 suppressed T cell lines specific for varying gp120 epitopes but did not affect T cell proliferation to non-HIV antigens. Moreover, inhibition by the anti-CD4bd/gp120 complexes was observed regardless of the types of antigen-presenting cells used to stimulate the T cells. These results indicate that the presence of anti-CD4bd antibodies complexed with gp120 can strongly suppress CD4+ helper T responses to gp120. | lld:pubmed |
| pubmed-article:10875615 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875615 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875615 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875615 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10875615 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875615 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10875615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10875615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10875615 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10875615 | pubmed:issn | 0889-2229 | lld:pubmed |
| pubmed-article:10875615 | pubmed:author | pubmed-author:GornyM KMK | lld:pubmed |
| pubmed-article:10875615 | pubmed:author | pubmed-author:Zolla-PaznerS... | lld:pubmed |
| pubmed-article:10875615 | pubmed:author | pubmed-author:JonesG JGJ | lld:pubmed |
| pubmed-article:10875615 | pubmed:author | pubmed-author:RaniRR | lld:pubmed |
| pubmed-article:10875615 | pubmed:author | pubmed-author:BiroMM | lld:pubmed |
| pubmed-article:10875615 | pubmed:author | pubmed-author:HioeC ECE | lld:pubmed |
| pubmed-article:10875615 | pubmed:author | pubmed-author:ReesA DAD | lld:pubmed |
| pubmed-article:10875615 | pubmed:author | pubmed-author:RunnA CAC | lld:pubmed |
| pubmed-article:10875615 | pubmed:author | pubmed-author:Ratto-KimSS | lld:pubmed |
| pubmed-article:10875615 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10875615 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:10875615 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:10875615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10875615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10875615 | pubmed:pagination | 893-905 | lld:pubmed |
| pubmed-article:10875615 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:meshHeading | pubmed-meshheading:10875615... | lld:pubmed |
| pubmed-article:10875615 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10875615 | pubmed:articleTitle | Anti-CD4-binding domain antibodies complexed with HIV type 1 glycoprotein 120 inhibit CD4+ T cell-proliferative responses to glycoprotein 120. | lld:pubmed |
| pubmed-article:10875615 | pubmed:affiliation | New York Veteran Affairs Medical Center and Department of Pathology, New York University School of Medicine, New York 10010, USA. hioec01@med.nyu.edu | lld:pubmed |
| pubmed-article:10875615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10875615 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10875615 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10875615 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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