| pubmed-article:10866999 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10866999 | lifeskim:mentions | umls-concept:C0003211 | lld:lifeskim |
| pubmed-article:10866999 | lifeskim:mentions | umls-concept:C0033551 | lld:lifeskim |
| pubmed-article:10866999 | lifeskim:mentions | umls-concept:C0680727 | lld:lifeskim |
| pubmed-article:10866999 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10866999 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10866999 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:10866999 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10866999 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10866999 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10866999 | pubmed:issue | 36 | lld:pubmed |
| pubmed-article:10866999 | pubmed:dateCreated | 2000-10-13 | lld:pubmed |
| pubmed-article:10866999 | pubmed:abstractText | The efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) is considered to be a result of their inhibitory effect on cyclooxygenase (COX) activity. Here, we report that flufenamic acid shows two opposing effects on COX-2 expression; it induces COX-2 expression in the colon cancer cell line (HT-29) and macrophage cell line (RAW 264.7); conversely, it inhibits tumor necrosis factor alpha (TNFalpha)- or lipopolysaccharide (LPS)-induced COX-2 expression. This inhibition correlates with the suppression of TNFalpha- or LPS-induced NFkappaB activation by flufenamic acid. The inhibitor of extracellular signal-regulated protein kinase, p38, or NFkappaB does not affect the NSAID-induced COX-2 expression. These results suggest that the NSAID-induced COX-2 expression is not mediated through activation of NFkappaB and mitogen-activated protein kinases. An activator of peroxisome proliferator-activated receptor gamma, 15-deoxy-Delta(12,14)-prostaglandin J(2), also induces COX-2 expression and inhibits TNFalpha-induced NFkappaB activation and COX-2 expression. Flufenamic acid and 15-deoxy-Delta(12,14)-prostaglandin J(2) also inhibit LPS-induced expression of inducible form of nitric-oxide synthase and interleukin-1alpha in RAW 264.7 cells. Together, these results indicate that the NSAIDs inhibit mitogen-induced COX-2 expression while they induce COX-2 expression. Furthermore, the results suggest that the anti-inflammatory effects of flufenamic acid and some other NSAIDs are due to their inhibitory action on the mitogen-induced expression of COX-2 and downstream markers of inflammation in addition to their inhibitory effect on COX enzyme activity. | lld:pubmed |
| pubmed-article:10866999 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10866999 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10866999 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10866999 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10866999 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10866999 | pubmed:author | pubmed-author:HwangD HDH | lld:pubmed |
| pubmed-article:10866999 | pubmed:author | pubmed-author:LeeJ YJY | lld:pubmed |
| pubmed-article:10866999 | pubmed:author | pubmed-author:BoudreauM DMD | lld:pubmed |
| pubmed-article:10866999 | pubmed:author | pubmed-author:EnsSS | lld:pubmed |
| pubmed-article:10866999 | pubmed:author | pubmed-author:PaisJ PJP | lld:pubmed |
| pubmed-article:10866999 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10866999 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:10866999 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10866999 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10866999 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10866999 | pubmed:pagination | 28173-9 | lld:pubmed |
| pubmed-article:10866999 | pubmed:dateRevised | 2011-10-27 | lld:pubmed |
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| pubmed-article:10866999 | pubmed:meshHeading | pubmed-meshheading:10866999... | lld:pubmed |
| pubmed-article:10866999 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10866999 | pubmed:articleTitle | Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. | lld:pubmed |
| pubmed-article:10866999 | pubmed:affiliation | Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA. | lld:pubmed |
| pubmed-article:10866999 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10866999 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10866999 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10866999 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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