| pubmed-article:10864901 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10864901 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:10864901 | lifeskim:mentions | umls-concept:C0596981 | lld:lifeskim |
| pubmed-article:10864901 | lifeskim:mentions | umls-concept:C1184146 | lld:lifeskim |
| pubmed-article:10864901 | lifeskim:mentions | umls-concept:C0221464 | lld:lifeskim |
| pubmed-article:10864901 | lifeskim:mentions | umls-concept:C0288263 | lld:lifeskim |
| pubmed-article:10864901 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:10864901 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:10864901 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:10864901 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10864901 | lifeskim:mentions | umls-concept:C0062565 | lld:lifeskim |
| pubmed-article:10864901 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:10864901 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:10864901 | pubmed:dateCreated | 2000-8-2 | lld:pubmed |
| pubmed-article:10864901 | pubmed:abstractText | The effects of protein-tyrosine kinase (PTK) and protein-tyrosine phosphatase (PTP) inhibitors on voltage-activated barium currents (I(Ba)) through L-type calcium channels increased by hypotonic solution were investigated in canine basilar arterial myocytes by the whole-cell patch-clamp technique. I(Ba) was elicited by depolarizing step from a holding potential of -80 to +10 mV and identified by using an L-type calcium channel agonist, Bay K 8644 (100 nM), and an L-type calcium channel blocker, nicardipine (1 microM). Hypotonic superfusate induced cell swelling and acted as a stretch stimulus, which reversibly increased peak I(Ba) amplitude at +10 mV. I(Ba) was also decreased by nicardipine (1 microM) under the hypotonic condition. PTK inhibitors such as herbimycin A (30 nM), genistein (10 microM), and lavendustin A (10 microM) decreased I(Ba) enhanced by hypotonic solution. Genistein also decreased I(Ba) in a concentration-dependent manner under the isotonic condition. The inactive genistein analogue daidzein (10 microM) had no effect on I(Ba) under either the isotonic or hypotonic condition. By contrast, herbimycin A did not decrease I(Ba) under the isotonic condition. Sodium orthovanadate (10 microM), a PTP inhibitor, increased I(Ba) under both conditions. The present results suggest that cell swelling by hypotonic solution increases the L-type calcium channel currents in canine basilar artery and that herbimycin-sensitive PTK activity is primarily involved in the enhancement of calcium channel currents. | lld:pubmed |
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| pubmed-article:10864901 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10864901 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10864901 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10864901 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10864901 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10864901 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:10864901 | pubmed:author | pubmed-author:NakayamaKK | lld:pubmed |
| pubmed-article:10864901 | pubmed:author | pubmed-author:IshikawaTT | lld:pubmed |
| pubmed-article:10864901 | pubmed:author | pubmed-author:KimuraMM | lld:pubmed |
| pubmed-article:10864901 | pubmed:author | pubmed-author:TanabeYY | lld:pubmed |
| pubmed-article:10864901 | pubmed:author | pubmed-author:ObaraKK | lld:pubmed |
| pubmed-article:10864901 | pubmed:author | pubmed-author:SasaseTT | lld:pubmed |
| pubmed-article:10864901 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10864901 | pubmed:volume | 130 | lld:pubmed |
| pubmed-article:10864901 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10864901 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10864901 | pubmed:pagination | 923-31 | lld:pubmed |
| pubmed-article:10864901 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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