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pubmed-article:10863076pubmed:abstractTextThe lung is the major dose-limiting organ for radiotherapy of cancer in the thoracic region. The pathogenesis of radiation-induced lung injury at the molecular level is still unclear. Immediate cellular damage after irradiation is supposed to result in cytokine-mediated multicellular interactions with induction and progression of fibrotic tissue reactions. The purpose of this investigation was to evaluate the acute and long-term effects of radiation on the gene expression of transforming growth factor beta (TGF-beta) in a model of lung injury using fibrosis-sensitive C57BL/6 mice.lld:pubmed
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pubmed-article:10863076pubmed:articleTitleDose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiation.lld:pubmed
pubmed-article:10863076pubmed:affiliationDepartment of Radiooncology, University of Munster, Munster, Germany. ruebe@med-rz.uni-saarland.delld:pubmed
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