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pubmed-article:10861743pubmed:abstractTextAn elucidation of the complex, morphological and molecular changes that underlie benign and malignant prostatic disease will likely lead to improved methods of diagnosis and therapy for those disorders. To identify and understand the interrelation of the phenotypic and genetic changes inherent in these important diseases requires the development and use of in vivo and in vitro models that closely mimic specific aspects of the disease process. Once the suspected molecular underpinnings of prostatic disease are uncovered, in vivo and in vitro models will be required for further testing of the functional significance of specific genetic alterations as they are identified. In addition models of prostatic disease are necessary to evaluate novel therapeutic approaches.lld:pubmed
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pubmed-article:10861743pubmed:authorpubmed-author:ParkS HSHlld:pubmed
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pubmed-article:10861743pubmed:authorpubmed-author:TimmeT LTLlld:pubmed
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pubmed-article:10861743pubmed:copyrightInfoCopyright 2000 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:10861743pubmed:pagination248-54lld:pubmed
pubmed-article:10861743pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:10861743pubmed:articleTitleMouse prostate reconstitution model system: A series of in vivo and in vitro models for benign and malignant prostatic disease.lld:pubmed
pubmed-article:10861743pubmed:affiliationScott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA. timothyt@www.urol.bcm.tmc.edulld:pubmed
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