| pubmed-article:10856254 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10856254 | lifeskim:mentions | umls-concept:C0011519 | lld:lifeskim |
| pubmed-article:10856254 | lifeskim:mentions | umls-concept:C0444626 | lld:lifeskim |
| pubmed-article:10856254 | lifeskim:mentions | umls-concept:C1336767 | lld:lifeskim |
| pubmed-article:10856254 | lifeskim:mentions | umls-concept:C0456378 | lld:lifeskim |
| pubmed-article:10856254 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10856254 | pubmed:dateCreated | 2000-8-7 | lld:pubmed |
| pubmed-article:10856254 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:abstractText | NAE:I is transformed from DNA endonuclease to DNA topoisomerase and recombinase by a single amino acid substitution. The crystal structure of NAE:I was solved at 2.3 A resolution and shows that NAE:I is a dimeric molecule with two domains per monomer. Each domain contains one potential DNA recognition motif corresponding to either endonuclease or topoisomerase activity. The N-terminal domain core folds like the other type II restriction endonucleases as well as lambda-exonuclease and the DNA repair enzymes MutH and Vsr, implying a common evolutionary origin and catalytic mechanism. The C-terminal domain contains a catabolite activator protein (CAP) motif present in many DNA-binding proteins, including the type IA and type II topoisomerases. Thus, the NAE:I structure implies that DNA processing enzymes evolved from a few common ancestors. NAE:I may be an evolutionary bridge between endonuclease and DNA processing enzymes. | lld:pubmed |
| pubmed-article:10856254 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10856254 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10856254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10856254 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10856254 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10856254 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:10856254 | pubmed:author | pubmed-author:TopalM DMD | lld:pubmed |
| pubmed-article:10856254 | pubmed:author | pubmed-author:ChenYY | lld:pubmed |
| pubmed-article:10856254 | pubmed:author | pubmed-author:LuxOO | lld:pubmed |
| pubmed-article:10856254 | pubmed:author | pubmed-author:ZhaiSS | lld:pubmed |
| pubmed-article:10856254 | pubmed:author | pubmed-author:KOVV | lld:pubmed |
| pubmed-article:10856254 | pubmed:author | pubmed-author:ColandeneJ... | lld:pubmed |
| pubmed-article:10856254 | pubmed:author | pubmed-author:HuaiQQ | lld:pubmed |
| pubmed-article:10856254 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10856254 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10856254 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:10856254 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10856254 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10856254 | pubmed:pagination | 3110-8 | lld:pubmed |
| pubmed-article:10856254 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:meshHeading | pubmed-meshheading:10856254... | lld:pubmed |
| pubmed-article:10856254 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10856254 | pubmed:articleTitle | Crystal structure of NaeI-an evolutionary bridge between DNA endonuclease and topoisomerase. | lld:pubmed |
