| pubmed-article:10849261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10849261 | lifeskim:mentions | umls-concept:C0369335 | lld:lifeskim |
| pubmed-article:10849261 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:10849261 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:10849261 | lifeskim:mentions | umls-concept:C0524910 | lld:lifeskim |
| pubmed-article:10849261 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:10849261 | lifeskim:mentions | umls-concept:C0041703 | lld:lifeskim |
| pubmed-article:10849261 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10849261 | pubmed:dateCreated | 2000-7-28 | lld:pubmed |
| pubmed-article:10849261 | pubmed:abstractText | Hepatitis C virus (HCV) RNA status and HCV genotype have become important tools in the diagnosis and monitoring of therapy in chronic HCV infection. To establish a database with respect to HCV genotype and serum HCV RNA concentrations in chronic hepatitis C patients in the United States, we analysed 6807 chronic hepatitis C patients who had HCV RNA and HCV genotype tests conducted at a central laboratory. The HCV RNA concentration cut-off for the lower 25th percentile of this population (low titre) was 0.9 x 106 copies ml-1. The median HCV RNA concentration was 3.5 x 106 copies ml-1 and the cut-off for the upper 25th percentile (high titre) was 5 x 106 copies ml-1. Male patients had a median HCV RNA concentration of 3.9 x 106 copies ml-1, which was significantly higher than the median HCV RNA level for females (2.75 x 106 copies ml-1; P < 0.001). HCV genotype 1 was detected in 73% of patients; genotype 2 in 14%; genotype 3 in 8%; mixed genotype in 4%; and genotypes 4, 5 and 6 with a frequency of < 1%. Patients from the Northeast, Southeast and Midwest had significantly (P < 0.001) more infections with genotype 1 than patients from the Western and Southern regions. African-American patients were more likely to be infected with genotype 1 when compared with Caucasian, Hispanic or Asian Pacific Islanders (P < 0.001). Patients infected with HCV genotype 1 and mixed HCV genotypes had significantly higher serum HCV RNA concentrations when compared with HCV genotypes 2 and 3 (P < 0.001 for all comparisons). | lld:pubmed |
| pubmed-article:10849261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10849261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10849261 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10849261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10849261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10849261 | pubmed:month | May | lld:pubmed |
| pubmed-article:10849261 | pubmed:issn | 1352-0504 | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:SchmidPP | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:TongM JMJ | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:SmithCC | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:HerreraJJ | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:ConradAA | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:BadaVV | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:MutchnickM... | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:TobiasHH | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:McHutchisonJ... | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:BlattL MLM | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:LebovicsEE | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:KlionF MFM | lld:pubmed |
| pubmed-article:10849261 | pubmed:author | pubmed-author:FreilichBB | lld:pubmed |
| pubmed-article:10849261 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10849261 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:10849261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10849261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10849261 | pubmed:pagination | 196-202 | lld:pubmed |
| pubmed-article:10849261 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10849261 | pubmed:meshHeading | pubmed-meshheading:10849261... | lld:pubmed |
| pubmed-article:10849261 | pubmed:meshHeading | pubmed-meshheading:10849261... | lld:pubmed |
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| pubmed-article:10849261 | pubmed:meshHeading | pubmed-meshheading:10849261... | lld:pubmed |
| pubmed-article:10849261 | pubmed:meshHeading | pubmed-meshheading:10849261... | lld:pubmed |
| pubmed-article:10849261 | pubmed:meshHeading | pubmed-meshheading:10849261... | lld:pubmed |
| pubmed-article:10849261 | pubmed:meshHeading | pubmed-meshheading:10849261... | lld:pubmed |
| pubmed-article:10849261 | pubmed:meshHeading | pubmed-meshheading:10849261... | lld:pubmed |
| pubmed-article:10849261 | pubmed:meshHeading | pubmed-meshheading:10849261... | lld:pubmed |
| pubmed-article:10849261 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10849261 | pubmed:articleTitle | Assessment of hepatitis C virus RNA and genotype from 6807 patients with chronic hepatitis C in the United States. | lld:pubmed |
| pubmed-article:10849261 | pubmed:affiliation | National Genetics Institute, Los Angeles, CA, USA. | lld:pubmed |
| pubmed-article:10849261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10849261 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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