| pubmed-article:10844517 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10844517 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:10844517 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10844517 | lifeskim:mentions | umls-concept:C0020517 | lld:lifeskim |
| pubmed-article:10844517 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:10844517 | lifeskim:mentions | umls-concept:C0417744 | lld:lifeskim |
| pubmed-article:10844517 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10844517 | lifeskim:mentions | umls-concept:C2709199 | lld:lifeskim |
| pubmed-article:10844517 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10844517 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10844517 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10844517 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10844517 | pubmed:dateCreated | 2000-6-27 | lld:pubmed |
| pubmed-article:10844517 | pubmed:abstractText | Recent studies have revealed the existence of a distinct type of NK cell leukaemia of the juvenile type, which presents with hypersensitivity to mosquito bites (HMB) as an essential clinical manifestation and is infected with clonal Epstein-Barr virus (EBV). This disorder is thus called HMB-EBV-NK disease and has been reported in Orientals, mostly from Japan. We investigated the profile of cytokine production and the expression of both types of NK inhibitory receptors, i.e. CD94 lectin-like dimers and killer-cell immunoglobulin-like receptors, in NK leukaemic cells from three patients with HMB-EBV-NK disease. It was found that freshly isolated NK leukaemic cells expressed mRNA for interferon-gamma (IFN-gamma) and additionally produced IL-10 upon stimulation with IL-2, indicating that the NK cells were of NK1 type. More than 98% of NK cells from the patients bore CD94 at a higher level than did normal NK cells, whereas p70 or NKAT2, belonging to immunoglobulin-like receptor, was not expressed in those NK cells. Freshly isolated leukaemic NK cells transcribed mRNA for CD94-associated molecule NKG2C at an abnormally high level, and upon stimulation with IL-2 and/or IL-12 they expressed NKG2A as well. The disordered expression of these inhibitory receptors not only provides some insights into the pathogenesis of HMB-EBV-NK disease but also can be used as phenotypic markers for the diagnosis of this type of NK cell leukaemia. | lld:pubmed |
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| pubmed-article:10844517 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10844517 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10844517 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10844517 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10844517 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10844517 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:10844517 | pubmed:author | pubmed-author:TakigawaMM | lld:pubmed |
| pubmed-article:10844517 | pubmed:author | pubmed-author:IshiharaSS | lld:pubmed |
| pubmed-article:10844517 | pubmed:author | pubmed-author:TagawaSS | lld:pubmed |
| pubmed-article:10844517 | pubmed:author | pubmed-author:TokuraYY | lld:pubmed |
| pubmed-article:10844517 | pubmed:author | pubmed-author:SeoNN | lld:pubmed |
| pubmed-article:10844517 | pubmed:author | pubmed-author:TakeokaYY | lld:pubmed |
| pubmed-article:10844517 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10844517 | pubmed:volume | 120 | lld:pubmed |
| pubmed-article:10844517 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10844517 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10844517 | pubmed:pagination | 413-9 | lld:pubmed |
| pubmed-article:10844517 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10844517 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10844517 | pubmed:articleTitle | Disordered expression of inhibitory receptors on the NK1-type natural killer (NK) leukaemic cells from patients with hypersensitivity to mosquito bites. | lld:pubmed |
| pubmed-article:10844517 | pubmed:affiliation | Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan. seo445@hama-med.ac.jp | lld:pubmed |
