| pubmed-article:10844412 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10844412 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10844412 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10844412 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:10844412 | lifeskim:mentions | umls-concept:C0009221 | lld:lifeskim |
| pubmed-article:10844412 | lifeskim:mentions | umls-concept:C0920563 | lld:lifeskim |
| pubmed-article:10844412 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
| pubmed-article:10844412 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10844412 | pubmed:dateCreated | 2000-7-24 | lld:pubmed |
| pubmed-article:10844412 | pubmed:abstractText | We investigated the relationship of codon 972 polymorphism of the insulin receptor substrate-1 (IRS-1) gene with insulin resistance in the Japanese population. Among 130 patients with type-2 diabetes mellitus (DM), we identified 6 who were heterozygous for the Gly972Arg mutation. Among 144 healthy subjects, 6 were heterozygous and 1 was homozygous for the mutation. A hyperinsulinemic euglycemic clamp study was performed in 3 of 6 diabetic patients with the heterozygous Gly972Arg mutation and in 60 without it. Both groups showed almost the same levels of insulin sensitivity (glucose infusion rate, GIR = 50.2 +/- 3.0 vs. 51.3 +/- 12.1 micromol/kg/min). Similarly, there was no difference in insulin sensitivity between healthy subjects with and without the mutation using the homeostasis model assessment (HOMA index = 1.14 +/- 0.50 vs. 1.02 +/- 0.63). The frequency of the Gly972Arg allele was not increased in diabetic patients compared with control subjects even in aged (>50 years old) or obese (BMI >/=25) subjects. Among healthy subjects, we identified a 25-year-old male with the homozygous Gly972Arg allele. He was slightly obese (BMI = 25.5) but showed relatively high insulin sensitivity, almost equal to that of healthy subjects without the mutation (GIR = 67.2 vs. 71.8 +/- 22.0 micromol/kg/min). Because the GIR in healthy subjects was significantly higher compared with that in type-2 DM patients, we speculate that another genetic or environmental factor producing a more deleterious effect on insulin sensitivity may exist in diabetic patients. We conclude that this gene abnormality does not play a role in the pathogenesis of insulin resistance and type-2 DM. | lld:pubmed |
| pubmed-article:10844412 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10844412 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10844412 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10844412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10844412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10844412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10844412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10844412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10844412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10844412 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10844412 | pubmed:issn | 0301-0163 | lld:pubmed |
| pubmed-article:10844412 | pubmed:author | pubmed-author:HoriYY | lld:pubmed |
| pubmed-article:10844412 | pubmed:author | pubmed-author:AdachiYY | lld:pubmed |
| pubmed-article:10844412 | pubmed:author | pubmed-author:ItoKK | lld:pubmed |
| pubmed-article:10844412 | pubmed:author | pubmed-author:FujiiMM | lld:pubmed |
| pubmed-article:10844412 | pubmed:author | pubmed-author:TsuchihashiKK | lld:pubmed |
| pubmed-article:10844412 | pubmed:author | pubmed-author:KatsukiAA | lld:pubmed |
| pubmed-article:10844412 | pubmed:author | pubmed-author:YanoYY | lld:pubmed |
| pubmed-article:10844412 | pubmed:author | pubmed-author:FurutaMM | lld:pubmed |
| pubmed-article:10844412 | pubmed:author | pubmed-author:SumidaYY | lld:pubmed |
| pubmed-article:10844412 | pubmed:copyrightInfo | Copyright 2000 S. Karger AG, Basel | lld:pubmed |
| pubmed-article:10844412 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10844412 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:10844412 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10844412 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10844412 | pubmed:pagination | 230-4 | lld:pubmed |
| pubmed-article:10844412 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10844412 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10844412 | pubmed:articleTitle | Insulin sensitivity is not affected by mutation of codon 972 of the human IRS-1 gene. | lld:pubmed |
| pubmed-article:10844412 | pubmed:affiliation | Third Department of Internal Medicine, Mie University School of Medicine, Mie, Japan. | lld:pubmed |
| pubmed-article:10844412 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10844412 | lld:pubmed |
