Linked Life Data

10843770

Source:http://linkedlifedata.com/resource/pubmed/id/10843770

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10843770rdf:typepubmed:Citationlld:pubmed
pubmed-article:10843770lifeskim:mentionsumls-concept:C1704256lld:lifeskim
pubmed-article:10843770lifeskim:mentionsumls-concept:C0229671lld:lifeskim
pubmed-article:10843770lifeskim:mentionsumls-concept:C2239176lld:lifeskim
pubmed-article:10843770lifeskim:mentionsumls-concept:C1749467lld:lifeskim
pubmed-article:10843770lifeskim:mentionsumls-concept:C0441889lld:lifeskim
pubmed-article:10843770lifeskim:mentionsumls-concept:C1539477lld:lifeskim
pubmed-article:10843770pubmed:issue6lld:pubmed
pubmed-article:10843770pubmed:dateCreated2000-8-23lld:pubmed
pubmed-article:10843770pubmed:abstractTextIn this study we assessed the usefulness of serum Transforming Growth Factor-beta1 (TGF-beta1) and soluble Fas (sFas) in distinguishing liver cirrhosis (LC) with and without hepatocellular carcinoma (HCC) as compared with alpha-fetoprotein (AFP). Serum TGF-beta1 and sFas levels were measured by ELISA in 51 LC patients, 54 patients with HCC and 30 healthy donors. Considering as a cut-off limit (mean+1SD of controls) 74 pg/ml and 637 pg/ml for TGF-beta1 and sFas, respectively, we computed serum concentrations of TGF-beta1 and sFas as a score (mean+/-SD). The positive frequency of serum TGF-beta1 levels in HCC patients (54%) was greater than in LC patients (26%) and healthy donors (3%). TGF-beta1 levels were higher in HCC (1.6+/-0.5) than in LC (1.1+/-0.2) (P<0.0001) and healthy donors (0.6+/-0.2). Using a cut-off limit of 82 pg/ml (mean+2SD), the positive frequency of TGF-beta1 was 20% in HCC patients. None of the controls and LC patients had TGF-beta1 levels higher than 82 pg/ml. The positive frequency of serum sFas levels was 100% in HCC patients, 98% in LC patients and 3% in healthy controls. Serum sFas levels were higher in HCC (2.5+/-0.7) than in LC (1.9+/-0.5) (P<0. 001) and healthy donors (0.6+/-0.3). No significant change of positive frequency was obtained by setting sFas cut-off at higher levels. sFas values did not correlate with TGF-beta1 levels. No relationship was found between TGF-beta1 amounts and AFP levels. However, in the 23% of HCC patients, with normal AFP values TGF-beta1 levels were higher than the cut off. These findings suggest the potential usefulness for TGF-beta1 assay in AFP-negative HCC.lld:pubmed
pubmed-article:10843770pubmed:languageenglld:pubmed
pubmed-article:10843770pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10843770pubmed:citationSubsetIMlld:pubmed
pubmed-article:10843770pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10843770pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10843770pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10843770pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10843770pubmed:statusMEDLINElld:pubmed
pubmed-article:10843770pubmed:monthJunlld:pubmed
pubmed-article:10843770pubmed:issn1043-4666lld:pubmed
pubmed-article:10843770pubmed:authorpubmed-author:AntonaciSSlld:pubmed
pubmed-article:10843770pubmed:authorpubmed-author:FioreGGlld:pubmed
pubmed-article:10843770pubmed:authorpubmed-author:SchiraldiOOlld:pubmed
pubmed-article:10843770pubmed:authorpubmed-author:SaccoRRlld:pubmed
pubmed-article:10843770pubmed:authorpubmed-author:TortorellaCClld:pubmed
pubmed-article:10843770pubmed:authorpubmed-author:MarinosciFFlld:pubmed
pubmed-article:10843770pubmed:authorpubmed-author:LeuciDDlld:pubmed
pubmed-article:10843770pubmed:copyrightInfoCopyright 2000 Academic Press.lld:pubmed
pubmed-article:10843770pubmed:issnTypePrintlld:pubmed
pubmed-article:10843770pubmed:volume12lld:pubmed
pubmed-article:10843770pubmed:ownerNLMlld:pubmed
pubmed-article:10843770pubmed:authorsCompleteYlld:pubmed
pubmed-article:10843770pubmed:pagination811-4lld:pubmed
pubmed-article:10843770pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:meshHeadingpubmed-meshheading:10843770...lld:pubmed
pubmed-article:10843770pubmed:year2000lld:pubmed
pubmed-article:10843770pubmed:articleTitleTransforming growth factor beta1 and soluble Fas serum levels in hepatocellular carcinoma.lld:pubmed
pubmed-article:10843770pubmed:affiliationDepartment of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Policlinico, Bari, 70124, Italy. saccorodolfo@hotmail.comlld:pubmed
pubmed-article:10843770pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10843770pubmed:publicationTypeComparative Studylld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10843770lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10843770lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10843770lld:pubmed