| pubmed-article:10842184 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10842184 | lifeskim:mentions | umls-concept:C1334291 | lld:lifeskim |
| pubmed-article:10842184 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10842184 | lifeskim:mentions | umls-concept:C0034839 | lld:lifeskim |
| pubmed-article:10842184 | lifeskim:mentions | umls-concept:C0815047 | lld:lifeskim |
| pubmed-article:10842184 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10842184 | lifeskim:mentions | umls-concept:C1160192 | lld:lifeskim |
| pubmed-article:10842184 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:10842184 | pubmed:issue | 36 | lld:pubmed |
| pubmed-article:10842184 | pubmed:dateCreated | 2000-10-13 | lld:pubmed |
| pubmed-article:10842184 | pubmed:abstractText | Signal regulatory proteins (SIRPs) are receptor-like transmembrane proteins, the majority of which contain a cytoplasmic proline-rich region and four cytoplasmic tyrosines that, when phosphorylated, bind SH2 domain-containing protein tyrosine phosphatases (SHP). We demonstrated previously that growth hormone (GH) induces tyrosyl phosphorylation of SIRPalpha and association of SIRPalpha with SHP-2. The GH-activated tyrosine kinase JAK2 associates with and tyrosyl-phosphorylates SIRPalpha1. Here we show that JAK2-SIRPalpha1 association does not require phosphotyrosines in SIRPalpha1 or JAK2 or the proline-rich region of SIRPalpha1. However, when the C-terminal 30 amino acids of SIRPalpha1 containing the proline-rich region and tyrosine 495 are deleted, tyrosyl phosphorylation of SIRPalpha1 by JAK2 and association of SHP-2 with SIRPalpha1 are reduced. GH-dependent tyrosyl phosphorylation of JAK2 is reduced when wild-type SIRPalpha1 compared with SIRPalpha1 lacking the four cytoplasmic tyrosines (SIRP 4YF) is expressed in cells, suggesting that SIRPalpha1 negatively regulates GHR/JAK2 signaling. Consistent with reduced JAK2 activity, overexpression of wild-type SIRPalpha1 but not SIRP 4YF reduces GH-induced phosphorylation of ERKs 1 and 2, STAT3, and STAT5B. These results suggest that SIRPalpha1 is a negative regulator of GH signaling and that the ability of SIRPalpha1 mutants to negatively regulate GHR-JAK2 signaling correlates with their ability to bind SHP-2. | lld:pubmed |
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| pubmed-article:10842184 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10842184 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10842184 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10842184 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10842184 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10842184 | pubmed:author | pubmed-author:UllrichAA | lld:pubmed |
| pubmed-article:10842184 | pubmed:author | pubmed-author:WangHH | lld:pubmed |
| pubmed-article:10842184 | pubmed:author | pubmed-author:Carter-SuCC | lld:pubmed |
| pubmed-article:10842184 | pubmed:author | pubmed-author:ArgetsingerL... | lld:pubmed |
| pubmed-article:10842184 | pubmed:author | pubmed-author:StofegaM RMR | lld:pubmed |
| pubmed-article:10842184 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10842184 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:10842184 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10842184 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10842184 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10842184 | pubmed:pagination | 28222-9 | lld:pubmed |
| pubmed-article:10842184 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10842184 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10842184 | pubmed:articleTitle | Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha. | lld:pubmed |
| pubmed-article:10842184 | pubmed:affiliation | Department of Microbiology and Immunology and Department of Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | lld:pubmed |
| pubmed-article:10842184 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10842184 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10842184 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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