| pubmed-article:10841661 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10841661 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:10841661 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:10841661 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10841661 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10841661 | lifeskim:mentions | umls-concept:C0393639 | lld:lifeskim |
| pubmed-article:10841661 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10841661 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10841661 | lifeskim:mentions | umls-concept:C1524003 | lld:lifeskim |
| pubmed-article:10841661 | lifeskim:mentions | umls-concept:C0533932 | lld:lifeskim |
| pubmed-article:10841661 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10841661 | pubmed:dateCreated | 2000-5-22 | lld:pubmed |
| pubmed-article:10841661 | pubmed:abstractText | In multiple sclerosis (MS) patients who carry the Class II major histocompatibility (MHC) type HLA-DR2, T cells specific for amino acids 95-116 in the proteolipid protein (PLP) are activated and clonally expanded. However, it remains unclear whether these autoreactive T cells play a pathogenic role or, rather, protect against the central nervous system (CNS) damage. We have addressed this issue, using mice transgenic for the human MHC class II region carrying the HLA-DR2 (DRB1* 1502) haplotype. After stimulating cultured lymph node cells repeatedly with PLP95-116, we generated 2 HLA-DR2-restricted, PLP95-116-specific T-cell lines (TCLs) from the transgenic mice immunized with this portion of PLP. The TCLs were CD4+ and produced T-helper 1 (Th1) cytokines in response to the peptide. These TCLs were adoptively transferred into RAG-2/2 mice expressing HLA-DR2 (DRG1* 1502) molecules. Mice receiving 1 of the TCLs developed a neurological disorder manifested ataxic movement without apparent paresis on day 3, 4, or 5 after cell transfer. Histological examination revealed inflammatory foci primarily restricted to the cerebrum and cerebellum, in association with scattered demyelinating lesions in the deep cerebral cortex. These results support a pathogenic role for PLP95-116-specific T cells in HLA-DR2+ MS patients, and shed light on the possible correlation between autoimmune target epitope and disease phenotype in human CNS autoimmune diseases. | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10841661 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10841661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10841661 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10841661 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10841661 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:10841661 | pubmed:author | pubmed-author:SasazukiTT | lld:pubmed |
| pubmed-article:10841661 | pubmed:author | pubmed-author:KawamuraKK | lld:pubmed |
| pubmed-article:10841661 | pubmed:author | pubmed-author:DavidC SCS | lld:pubmed |
| pubmed-article:10841661 | pubmed:author | pubmed-author:TabiraTT | lld:pubmed |
| pubmed-article:10841661 | pubmed:author | pubmed-author:YamamuraTT | lld:pubmed |
| pubmed-article:10841661 | pubmed:author | pubmed-author:FukuiYY | lld:pubmed |
| pubmed-article:10841661 | pubmed:author | pubmed-author:YokoyamaKK | lld:pubmed |
| pubmed-article:10841661 | pubmed:author | pubmed-author:ChuiD HDH | lld:pubmed |
| pubmed-article:10841661 | pubmed:author | pubmed-author:InokoHH | lld:pubmed |
| pubmed-article:10841661 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10841661 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:10841661 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10841661 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10841661 | pubmed:pagination | 977-84 | lld:pubmed |
| pubmed-article:10841661 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:meshHeading | pubmed-meshheading:10841661... | lld:pubmed |
| pubmed-article:10841661 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10841661 | pubmed:articleTitle | Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. | lld:pubmed |
