| pubmed-article:1083701 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1083701 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1083701 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:1083701 | lifeskim:mentions | umls-concept:C0034067 | lld:lifeskim |
| pubmed-article:1083701 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1083701 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1083701 | pubmed:dateCreated | 1976-7-6 | lld:pubmed |
| pubmed-article:1083701 | pubmed:abstractText | The possibility that human alpha1-antitrypsin could effectively prevent development of emphysematous lesions produced in hamsters 7 days after exposure to aerosolized papain (3% for 3 hours) was investigated. Pretreatment with intratracheal human alpha1-antitrypsin prevented the appearance of these lesions in a dose-dependent manner. On the other hand, systemic administration of large doses of human alpha1-antitrypsin failed to prevent papain-induced pulmonary lesions, despite a significant increase in serum trypsin inhibitory capacity. These results suggest that intra-alveolar rather than serum concentrations of human alpha1-antitrypsin are critical for preventing the development of pulmonary emphysema in this animal model. It is interesting that although the mechanism by which human alpha1-antitrypsin prevented the papain-induced lesions is unknown, intratracheally administered human alpha1-antitrypsin similarly prevented the development of pulmonary emphysematous lesions induced by 0.1 mg of porcine pancreatic elastase given intratracheally. | lld:pubmed |
| pubmed-article:1083701 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1083701 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1083701 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1083701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1083701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1083701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1083701 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1083701 | pubmed:month | May | lld:pubmed |
| pubmed-article:1083701 | pubmed:issn | 0003-0805 | lld:pubmed |
| pubmed-article:1083701 | pubmed:author | pubmed-author:ShareN NNN | lld:pubmed |
| pubmed-article:1083701 | pubmed:author | pubmed-author:MartoranaP... | lld:pubmed |
| pubmed-article:1083701 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1083701 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:1083701 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1083701 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1083701 | pubmed:pagination | 607-12 | lld:pubmed |
| pubmed-article:1083701 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:1083701 | pubmed:meshHeading | pubmed-meshheading:1083701-... | lld:pubmed |
| pubmed-article:1083701 | pubmed:meshHeading | pubmed-meshheading:1083701-... | lld:pubmed |
| pubmed-article:1083701 | pubmed:meshHeading | pubmed-meshheading:1083701-... | lld:pubmed |
| pubmed-article:1083701 | pubmed:meshHeading | pubmed-meshheading:1083701-... | lld:pubmed |
| pubmed-article:1083701 | pubmed:meshHeading | pubmed-meshheading:1083701-... | lld:pubmed |
| pubmed-article:1083701 | pubmed:meshHeading | pubmed-meshheading:1083701-... | lld:pubmed |
| pubmed-article:1083701 | pubmed:meshHeading | pubmed-meshheading:1083701-... | lld:pubmed |
| pubmed-article:1083701 | pubmed:meshHeading | pubmed-meshheading:1083701-... | lld:pubmed |
| pubmed-article:1083701 | pubmed:meshHeading | pubmed-meshheading:1083701-... | lld:pubmed |
| pubmed-article:1083701 | pubmed:meshHeading | pubmed-meshheading:1083701-... | lld:pubmed |
| pubmed-article:1083701 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:1083701 | pubmed:articleTitle | Effect of human alpha-antitrypsin in papain-induced emphysema in the hamster. | lld:pubmed |
| pubmed-article:1083701 | pubmed:publicationType | Journal Article | lld:pubmed |
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