| pubmed-article:10835356 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C0143630 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C1570804 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C0041538 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C0663914 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C2348445 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C1366480 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C1417708 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C1422597 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C1709694 | lld:lifeskim |
| pubmed-article:10835356 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:10835356 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:10835356 | pubmed:dateCreated | 2000-7-20 | lld:pubmed |
| pubmed-article:10835356 | pubmed:abstractText | Processing of the p105 precursor to form the active subunit p50 of the NF-kappaB transcription factor is a unique case in which the ubiquitin system is involved in limited processing rather than in complete destruction of the target substrate. A glycine-rich region along with a downstream acidic domain have been demonstrated to be essential for processing. Here we demonstrate that following IkappaB kinase (IkappaK)-mediated phosphorylation, the C-terminal domain of p105 (residues 918-934) serves as a recognition motif for the SCF(beta)(-TrCP) ubiquitin ligase. Expression of IkappaKbeta dramatically increases processing of wild-type p105, but not of p105-Delta918-934. Dominant-negative beta-TrCP inhibits IkappaK-dependent processing. Furthermore, the ligase and wild-type p105 but not p105-Delta918-934 associate physically following phosphorylation. In vitro, SCF(beta)(-TrCP) specifically conjugates and promotes processing of phosphorylated p105. Importantly, the TrCP recognition motif in p105 is different from that described for IkappaBs, beta-catenin and human immunodeficiency virus type 1 Vpu. Since p105-Delta918-934 is also conjugated and processed, it appears that p105 can be recognized under different physiological conditions by two different ligases, targeting two distinct recognition motifs. | lld:pubmed |
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| pubmed-article:10835356 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10835356 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10835356 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10835356 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10835356 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10835356 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10835356 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10835356 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10835356 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:10835356 | pubmed:author | pubmed-author:IwaiKK | lld:pubmed |
| pubmed-article:10835356 | pubmed:author | pubmed-author:EytanEE | lld:pubmed |
| pubmed-article:10835356 | pubmed:author | pubmed-author:SchwartzA LAL | lld:pubmed |
| pubmed-article:10835356 | pubmed:author | pubmed-author:IsraëlAA | lld:pubmed |
| pubmed-article:10835356 | pubmed:author | pubmed-author:CiechanoverAA | lld:pubmed |
| pubmed-article:10835356 | pubmed:author | pubmed-author:MercurioFF | lld:pubmed |
| pubmed-article:10835356 | pubmed:author | pubmed-author:BercoviciEE | lld:pubmed |
| pubmed-article:10835356 | pubmed:author | pubmed-author:GonenHH | lld:pubmed |
| pubmed-article:10835356 | pubmed:author | pubmed-author:OrianAA | lld:pubmed |
| pubmed-article:10835356 | pubmed:author | pubmed-author:FajermanII | lld:pubmed |
| pubmed-article:10835356 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10835356 | pubmed:day | 1 | lld:pubmed |
