| pubmed-article:108291 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:108291 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:108291 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:108291 | lifeskim:mentions | umls-concept:C0042971 | lld:lifeskim |
| pubmed-article:108291 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:108291 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:108291 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:108291 | lifeskim:mentions | umls-concept:C2756228 | lld:lifeskim |
| pubmed-article:108291 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:108291 | pubmed:dateCreated | 1979-7-25 | lld:pubmed |
| pubmed-article:108291 | pubmed:abstractText | The presence of specific Factor VIII/von Willebrand factor (FVIII/vWF) binding sites on human platelets has been demonstrated by using 125I-FVIII/vWF and washed human platelets. Binding is ristocetin-dependent and increases in proportion to the concentration of ristocetin from 0.2 to 1 mg/ml. Binding of 125I-FVIII/vWF to platelets can be competitively inhibited by unlabeled human or bovine FVIII/vWF, but not by human thrombin, fibrinogen, alpha 2-macroglobulin, equine collagen, or a lectin of Ricinus communis. Scatchard analysis of binding data indicated that the dissociation constant of FVIII/vWF receptors is 0.45--0.5 nM. There are 31,000 binding sites per platelet at 1 mg/ml of ristocetin concentration. The optimal pH range for binding is from 7.0 to 7.5. At a concentration of 2 mM, EGTA inhibits 86% of the binding; however, 20 mM of Ca++, Mg++, or EDTA have little effect. Binding sites for FVIII/vWF were found only on platelets, and no significant binding was detected with human erythrocytes or polymorphonuclear leukocytes. | lld:pubmed |
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| pubmed-article:108291 | pubmed:language | eng | lld:pubmed |
| pubmed-article:108291 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:108291 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:108291 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:108291 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:108291 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:108291 | pubmed:author | pubmed-author:McKeeP APA | lld:pubmed |
| pubmed-article:108291 | pubmed:author | pubmed-author:PizzoS VSV | lld:pubmed |
| pubmed-article:108291 | pubmed:author | pubmed-author:LinH UHU | lld:pubmed |
| pubmed-article:108291 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:108291 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:108291 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:108291 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:108291 | pubmed:pagination | 656-64 | lld:pubmed |
| pubmed-article:108291 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:108291 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:108291 | pubmed:articleTitle | Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets. | lld:pubmed |
| pubmed-article:108291 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:108291 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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