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pubmed-article:10828710lifeskim:mentionsumls-concept:C0042136lld:lifeskim
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pubmed-article:10828710pubmed:dateCreated2000-8-11lld:pubmed
pubmed-article:10828710pubmed:abstractTextImplantation of intrauterine devices (IUDs) is associated with an increased incidence of uterine infection, probably as a result of vaginal bacteria entering the uterus at the time of insertion. To reduce the incidence of IUD-related infections, the incorporation of antimicrobial agents into the tail of the device was studied. Chlorhexidine was shown to be released from within nylon hollow fibres at a rate of approximately 114 microg x day(-1) for 10 days. This rate of release was sufficient to exhibit a biocidal effect on bacteria embedded within a mucus gel in vitro. When these devices were implanted transcervically into the guinea-pig uterus they significantly reduced the extent of uterine bacterial contamination within 24 h. These findings indicate that chlorhexidine-releasing devices are potentially useful in the reduction of device-related infections.lld:pubmed
pubmed-article:10828710pubmed:languageenglld:pubmed
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pubmed-article:10828710pubmed:issn0378-7346lld:pubmed
pubmed-article:10828710pubmed:authorpubmed-author:HanlonG WGWlld:pubmed
pubmed-article:10828710pubmed:authorpubmed-author:GrayG FGFlld:pubmed
pubmed-article:10828710pubmed:authorpubmed-author:ReynoldsJ PJPlld:pubmed
pubmed-article:10828710pubmed:copyrightInfoCopyright 2000 S. Karger AG, Basellld:pubmed
pubmed-article:10828710pubmed:issnTypePrintlld:pubmed
pubmed-article:10828710pubmed:volume49lld:pubmed
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pubmed-article:10828710pubmed:pagination261-5lld:pubmed
pubmed-article:10828710pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:10828710pubmed:year2000lld:pubmed
pubmed-article:10828710pubmed:articleTitleUse of chlorhexidine-releasing nylon fibres to reduce device-related uterine infections.lld:pubmed
pubmed-article:10828710pubmed:affiliationSchool of Pharmacy and Biomolecular Sciences, University of Brighton, UK. p.r.gard@brighton.ac.uklld:pubmed
pubmed-article:10828710pubmed:publicationTypeJournal Articlelld:pubmed