| pubmed-article:10828269 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10828269 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10828269 | lifeskim:mentions | umls-concept:C0000970 | lld:lifeskim |
| pubmed-article:10828269 | lifeskim:mentions | umls-concept:C0085403 | lld:lifeskim |
| pubmed-article:10828269 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10828269 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:10828269 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:10828269 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10828269 | pubmed:dateCreated | 2000-7-11 | lld:pubmed |
| pubmed-article:10828269 | pubmed:abstractText | A toxic dose of acetaminophen (APAP) reduces the activity of NF-kappaB in mouse liver. NF-kappaB inactivation may be important for APAP toxicity, as this transcription factor can play a central role in maintaining hepatic viability. We recently reported that APAP likewise inhibits serum growth factor activation of NF-kappaB in a mouse hepatoma cell line (Hepa 1-6 cells). Here we present evidence that APAP's antioxidant activity may be involved in this NF-kappaB inhibition in Hepa 1-6 cells. Like the antioxidants N-acetylcysteine (NAC) and pyrrolidinedithiocarbamate (PDTC), APAP was found to suppress the H(2)O(2)-induced oxidation of an intracellular reactive oxygen species probe (dihydrodichlorofluorescein) in Hepa 1-6 cells. Treatment of Hepa 1-6 cells with H(2)O(2) was sufficient for NF-kappaB activation and IkappaBalpha degradation, and APAP was able to block both of these events. The APAP inhibition of NF-kappaB activation by serum growth factors may also be due to APAP's antioxidant activity, as the antioxidants NAC and PDTC likewise inhibit this activation. The potential role of NF-kappaB and oxidant-based growth factor signal transduction in APAP toxicity is discussed. | lld:pubmed |
| pubmed-article:10828269 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10828269 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828269 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10828269 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10828269 | pubmed:issn | 1096-6080 | lld:pubmed |
| pubmed-article:10828269 | pubmed:author | pubmed-author:KhairallahE... | lld:pubmed |
| pubmed-article:10828269 | pubmed:author | pubmed-author:CohenS DSD | lld:pubmed |
| pubmed-article:10828269 | pubmed:author | pubmed-author:GiardinaCC | lld:pubmed |
| pubmed-article:10828269 | pubmed:author | pubmed-author:BoularesA HAH | lld:pubmed |
| pubmed-article:10828269 | pubmed:author | pubmed-author:MAGE | lld:pubmed |
| pubmed-article:10828269 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10828269 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:10828269 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10828269 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10828269 | pubmed:pagination | 370-5 | lld:pubmed |
| pubmed-article:10828269 | pubmed:dateRevised | 2010-9-17 | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:meshHeading | pubmed-meshheading:10828269... | lld:pubmed |
| pubmed-article:10828269 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10828269 | pubmed:articleTitle | Acetaminophen inhibits NF-kappaB activation by interfering with the oxidant signal in murine Hepa 1-6 cells. | lld:pubmed |
| pubmed-article:10828269 | pubmed:affiliation | Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269, USA. | lld:pubmed |
| pubmed-article:10828269 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10828269 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
