| pubmed-article:10828249 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10828249 | lifeskim:mentions | umls-concept:C0439826 | lld:lifeskim |
| pubmed-article:10828249 | lifeskim:mentions | umls-concept:C1160185 | lld:lifeskim |
| pubmed-article:10828249 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:10828249 | lifeskim:mentions | umls-concept:C1521871 | lld:lifeskim |
| pubmed-article:10828249 | lifeskim:mentions | umls-concept:C0038078 | lld:lifeskim |
| pubmed-article:10828249 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10828249 | lifeskim:mentions | umls-concept:C1261552 | lld:lifeskim |
| pubmed-article:10828249 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10828249 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10828249 | pubmed:dateCreated | 2000-7-21 | lld:pubmed |
| pubmed-article:10828249 | pubmed:abstractText | Olfactory receptor neurons (ORNs) from the squid, Lolliguncula brevis, respond to the odors l-glutamate or dopamine with increases in internal Ca(2+) concentrations ([Ca(2+)](i)). To directly asses the effects of increasing [Ca(2+)](i) in perforated-patched squid ORNs, we applied 10 mM caffeine to release Ca(2+) from internal stores. We observed an inward current response to caffeine. Monovalent cation replacement of Na(+) from the external bath solution completely and selectively inhibited the caffeine-induced response, and ruled out the possibility of a Ca(2+)-dependent nonselective cation current. The strict dependence on internal Ca(2+) and external Na(+) indicated that the inward current was due to an electrogenic Na(+)/Ca(2+) exchanger. Block of the caffeine-induced current by an inhibitor of Na(+)/Ca(2+) exchange (50-100 microM 2',4'-dichlorobenzamil) and reversibility of the exchanger current, further confirmed its presence. We tested whether Na(+)/Ca(2+) exchange contributed to odor responses by applying the aquatic odor l-glutamate in the presence and absence of 2', 4'-dichlorobenzamil. We found that electrogenic Na(+)/Ca(2+) exchange was responsible for approximately 26% of the total current associated with glutamate-induced odor responses. Although Na(+)/Ca(2+) exchangers are known to be present in ORNs from numerous species, this is the first work to demonstrate amplifying contributions of the exchanger current to odor transduction. | lld:pubmed |
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| pubmed-article:10828249 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10828249 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10828249 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10828249 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10828249 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10828249 | pubmed:issn | 0022-1295 | lld:pubmed |
| pubmed-article:10828249 | pubmed:author | pubmed-author:LuceroM TMT | lld:pubmed |
| pubmed-article:10828249 | pubmed:author | pubmed-author:DanaceauJ PJP | lld:pubmed |
| pubmed-article:10828249 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10828249 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:10828249 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10828249 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10828249 | pubmed:pagination | 759-68 | lld:pubmed |
| pubmed-article:10828249 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10828249 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10828249 | pubmed:articleTitle | Electrogenic Na(+)/Ca(2+) exchange. A novel amplification step in squid olfactory transduction. | lld:pubmed |
| pubmed-article:10828249 | pubmed:affiliation | Interdepartmental Program in Neuroscience, School of Medicine, Salt Lake City, UT 84108, USA. | lld:pubmed |
| pubmed-article:10828249 | pubmed:publicationType | Journal Article | lld:pubmed |
