| pubmed-article:10826537 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10826537 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:10826537 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:10826537 | lifeskim:mentions | umls-concept:C0016911 | lld:lifeskim |
| pubmed-article:10826537 | lifeskim:mentions | umls-concept:C1519666 | lld:lifeskim |
| pubmed-article:10826537 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:10826537 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:10826537 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:10826537 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10826537 | pubmed:dateCreated | 2000-6-6 | lld:pubmed |
| pubmed-article:10826537 | pubmed:abstractText | Pathophysiologic parameters of the functional neovasculature and the blood-brain barrier of 9L-glioma in rat brain were measured noninvasively by dynamic 1H magnetic resonance imaging studies of gadolinium (Gd)-DTPA uptake. Changes of apparent [Gd-DTPA] uptake in time (CT[t]) were analyzed in a slice through the center of 10 9L-gliomas using fast T1 measurements. The distribution of the contrast agent was spatially correlated with the distribution of perfused microvessels as determined by immunohistochemical analysis. This method permits a distinction between perfused and nonperfused microvessels with a disrupted blood-brain barrier. In transverse slices of the whole tumor, a spatial correlation was observed between CT maps and the two-dimensional distribution of perfused microvessels. In the next step, Gd-DTPA uptake rates were spatially related to the perfused microvessel density (Np) or vascular surface area (Sp). In tumor voxels with perfused microvessels, a linear correlation was found between Gd-DTPA uptake rate constants (k values) and Np or Sp. No correlation was observed between k values and the total microvessel density. These are the first data that show a relation between Gd-DTPA uptake rates and parameters of the functional neovasculature in 9L-glioma growing in rat brain. Now that Gd-DTPA uptake studies can be related to parameters of the functional neovasculature, they may be used more efficiently as a prognostic tool before or during therapy. | lld:pubmed |
| pubmed-article:10826537 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10826537 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10826537 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10826537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10826537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10826537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10826537 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10826537 | pubmed:month | May | lld:pubmed |
| pubmed-article:10826537 | pubmed:issn | 0271-678X | lld:pubmed |
| pubmed-article:10826537 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:10826537 | pubmed:author | pubmed-author:BovéeW MWM | lld:pubmed |
| pubmed-article:10826537 | pubmed:author | pubmed-author:HeerschapAA | lld:pubmed |
| pubmed-article:10826537 | pubmed:author | pubmed-author:RozijnT HTH | lld:pubmed |
| pubmed-article:10826537 | pubmed:author | pubmed-author:PetersH PHP | lld:pubmed |
| pubmed-article:10826537 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:10826537 | pubmed:author | pubmed-author:RijkenP FPF | lld:pubmed |
| pubmed-article:10826537 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10826537 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:10826537 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10826537 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10826537 | pubmed:pagination | 861-70 | lld:pubmed |
| pubmed-article:10826537 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10826537 | pubmed:meshHeading | pubmed-meshheading:10826537... | lld:pubmed |
| pubmed-article:10826537 | pubmed:meshHeading | pubmed-meshheading:10826537... | lld:pubmed |
| pubmed-article:10826537 | pubmed:meshHeading | pubmed-meshheading:10826537... | lld:pubmed |
| pubmed-article:10826537 | pubmed:meshHeading | pubmed-meshheading:10826537... | lld:pubmed |
| pubmed-article:10826537 | pubmed:meshHeading | pubmed-meshheading:10826537... | lld:pubmed |
| pubmed-article:10826537 | pubmed:meshHeading | pubmed-meshheading:10826537... | lld:pubmed |
| pubmed-article:10826537 | pubmed:meshHeading | pubmed-meshheading:10826537... | lld:pubmed |
| pubmed-article:10826537 | pubmed:meshHeading | pubmed-meshheading:10826537... | lld:pubmed |
| pubmed-article:10826537 | pubmed:meshHeading | pubmed-meshheading:10826537... | lld:pubmed |
| pubmed-article:10826537 | pubmed:meshHeading | pubmed-meshheading:10826537... | lld:pubmed |
| pubmed-article:10826537 | pubmed:meshHeading | pubmed-meshheading:10826537... | lld:pubmed |
| pubmed-article:10826537 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10826537 | pubmed:articleTitle | Noninvasive assessment of the functional neovasculature in 9L-glioma growing in rat brain by dynamic 1H magnetic resonance imaging of gadolinium uptake. | lld:pubmed |
| pubmed-article:10826537 | pubmed:affiliation | Department of Radiology, University Hospital Nijmegen, The Netherlands. | lld:pubmed |
| pubmed-article:10826537 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10826537 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10826537 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10826537 | lld:pubmed |
