| pubmed-article:10825197 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10825197 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:10825197 | lifeskim:mentions | umls-concept:C0042153 | lld:lifeskim |
| pubmed-article:10825197 | lifeskim:mentions | umls-concept:C0149784 | lld:lifeskim |
| pubmed-article:10825197 | lifeskim:mentions | umls-concept:C0007009 | lld:lifeskim |
| pubmed-article:10825197 | lifeskim:mentions | umls-concept:C1148798 | lld:lifeskim |
| pubmed-article:10825197 | lifeskim:mentions | umls-concept:C1822807 | lld:lifeskim |
| pubmed-article:10825197 | lifeskim:mentions | umls-concept:C0449416 | lld:lifeskim |
| pubmed-article:10825197 | lifeskim:mentions | umls-concept:C1819626 | lld:lifeskim |
| pubmed-article:10825197 | lifeskim:mentions | umls-concept:C1517317 | lld:lifeskim |
| pubmed-article:10825197 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10825197 | pubmed:dateCreated | 2000-7-7 | lld:pubmed |
| pubmed-article:10825197 | pubmed:abstractText | In Saccharomyces cerevisiae, the family of ATF/CREB transcriptional regulators consists of a repressor, Acr1 (Sko1), and two activators, Aca1 and Aca2. The AP-1 factor Gen4 does not activate transcription through ATF/CREB sites in vivo even though it binds these sites in vitro. Unlike ATF/CREB activators in other species, Aca1- and Aca2-dependent transcription is not affected by protein kinase A or by stress, and Aca1 and Aca2 are not required for Hog1-dependent salt induction of transcription through an optimal ATF/CREB site. Aca2 is important for a variety of biological functions including growth on nonoptimal carbon sources, and Aca2-dependent activation is modestly regulated by carbon source. Strains lacking Aca1 are phenotypically normal, but overexpression of Aca1 suppresses some defects associated with the loss of Aca2, indicating a functional overlap between Aca1 and Aca2. Acr1 represses transcription both by recruiting the Cyc8-Tup1 corepressor and by directly competing with Aca1 and Aca2 for target sites. Acr1 does not fully account for osmotic regulation through ATF/CREB sites, and a novel Hog1-dependent activator(s) that is not a bZIP protein is required for ATF/CREB site activation in response to high salt. In addition, Acr1 does not affect a number of phenotypes that arise from loss of Aca2. Thus, members of the S. cerevisiae ATF/CREB family have overlapping, but distinct, biological functions and target genes. | lld:pubmed |
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| pubmed-article:10825197 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10825197 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825197 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10825197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10825197 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10825197 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10825197 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:10825197 | pubmed:author | pubmed-author:StruhlKK | lld:pubmed |
| pubmed-article:10825197 | pubmed:author | pubmed-author:Garcia-Gimeno... | lld:pubmed |
| pubmed-article:10825197 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10825197 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:10825197 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10825197 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10825197 | pubmed:pagination | 4340-9 | lld:pubmed |
