| pubmed-article:10825194 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C0334094 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C1709060 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C1516044 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:10825194 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:10825194 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10825194 | pubmed:dateCreated | 2000-7-7 | lld:pubmed |
| pubmed-article:10825194 | pubmed:abstractText | We have assayed the oncogenic, proliferative, and apoptotic activities of the frequent mutations that occur in the c-myc gene in Burkitt's lymphomas. Some alleles have a modest (50 to 60%) increase in transforming activity; however, the most frequent Burkitt's lymphoma allele (T58I) had an unexpected substantial decrease in transforming activity (85%). All alleles restored the proliferation function of c-Myc in cells that grow slowly due to a c-myc knockout. There was discordance for some alleles between apoptotic and oncogenic activities, but only the T58A allele had elevated transforming activity with a concomitant reduced apoptotic potential. We discovered a novel missense mutation, MycS71F, that had a very low apoptotic activity compared to wild-type Myc, yet this mutation has never been found in lymphomas, suggesting that there is no strong selection for antiapoptotic c-Myc alleles. MycS71F also induced very low levels of cytochrome c release from mitochondria, suggesting a mechanism of action for this mutation. Phosphopeptide mapping provided a biochemical basis for the dramatically different biological activities of the transformation-defective T58I and transformation-enhanced T58A c-Myc alleles. Furthermore, the antiapoptotic survival factor insulin-like growth factor 1 was found to suppress phosphorylation of T58, suggesting that the c-Myc transactivation domain is a direct target of survival signals. | lld:pubmed |
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| pubmed-article:10825194 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10825194 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825194 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10825194 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10825194 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10825194 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:10825194 | pubmed:author | pubmed-author:ColeM DMD | lld:pubmed |
| pubmed-article:10825194 | pubmed:author | pubmed-author:HannS RSR | lld:pubmed |
| pubmed-article:10825194 | pubmed:author | pubmed-author:ChangD WDW | lld:pubmed |
| pubmed-article:10825194 | pubmed:author | pubmed-author:ClaassenG FGF | lld:pubmed |
| pubmed-article:10825194 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10825194 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:10825194 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10825194 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10825194 | pubmed:pagination | 4309-19 | lld:pubmed |
| pubmed-article:10825194 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10825194 | pubmed:meshHeading | pubmed-meshheading:10825194... | lld:pubmed |
| pubmed-article:10825194 | pubmed:meshHeading | pubmed-meshheading:10825194... | lld:pubmed |
| pubmed-article:10825194 | pubmed:meshHeading | pubmed-meshheading:10825194... | lld:pubmed |
| pubmed-article:10825194 | pubmed:meshHeading | pubmed-meshheading:10825194... | lld:pubmed |
| pubmed-article:10825194 | pubmed:meshHeading | pubmed-meshheading:10825194... | lld:pubmed |
