| pubmed-article:10823800 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10823800 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:10823800 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:10823800 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10823800 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:10823800 | lifeskim:mentions | umls-concept:C0151332 | lld:lifeskim |
| pubmed-article:10823800 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:10823800 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10823800 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10823800 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10823800 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10823800 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:10823800 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10823800 | pubmed:dateCreated | 2000-7-20 | lld:pubmed |
| pubmed-article:10823800 | pubmed:abstractText | The purified protein derivative (PPD) skin test has no predictive value for tuberculosis (TB) in Mycobacterium bovis bacillus Calmette-Guérin (BCG)-vaccinated individuals because of cross-reactive responses to nonspecific constituents of PPD. T cell responses to early-secreted antigenic target 6-kDa protein (ESAT-6) and the newly identified culture filtrate protein 10 (CFP-10), 2 proteins specifically expressed by M. tuberculosis (MTB) but not by BCG strains, were evaluated. Most TB patients responded to ESAT-6 (92%) or CFP-10 (89%). A minority of BCG-vaccinated individuals responded to both ESAT-6 and CFP-10, their history being consistent with latent infection with MTB in the presence of protective immunity. No responses were found in PPD-negative controls. The sensitivity and specificity of the assay were 84% and 100%, respectively, at a cutoff of 300 pg of interferon-gamma/mL. These data indicate that ESAT-6 and CFP-10 are promising antigens for highly specific immunodiagnosis of TB, even in BCG-vaccinated individuals. | lld:pubmed |
| pubmed-article:10823800 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823800 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10823800 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823800 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10823800 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10823800 | pubmed:month | May | lld:pubmed |
| pubmed-article:10823800 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:10823800 | pubmed:author | pubmed-author:AndersenPP | lld:pubmed |
| pubmed-article:10823800 | pubmed:author | pubmed-author:OttenhoffT... | lld:pubmed |
| pubmed-article:10823800 | pubmed:author | pubmed-author:ArendS MSM | lld:pubmed |
| pubmed-article:10823800 | pubmed:author | pubmed-author:van DisselJ... | lld:pubmed |
| pubmed-article:10823800 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:10823800 | pubmed:author | pubmed-author:SkjotR LRL | lld:pubmed |
| pubmed-article:10823800 | pubmed:author | pubmed-author:SubrontoY WYW | lld:pubmed |
| pubmed-article:10823800 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10823800 | pubmed:volume | 181 | lld:pubmed |
| pubmed-article:10823800 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10823800 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10823800 | pubmed:pagination | 1850-4 | lld:pubmed |
| pubmed-article:10823800 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10823800 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10823800 | pubmed:articleTitle | Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10. | lld:pubmed |
| pubmed-article:10823800 | pubmed:affiliation | Dept. of Infectious Diseases, C5P, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. smarend@lumc.nl. | lld:pubmed |
| pubmed-article:10823800 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10823800 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10823800 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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