| pubmed-article:10823419 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10823419 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10823419 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:10823419 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10823419 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10823419 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10823419 | lifeskim:mentions | umls-concept:C1424685 | lld:lifeskim |
| pubmed-article:10823419 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:10823419 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10823419 | pubmed:dateCreated | 2000-6-1 | lld:pubmed |
| pubmed-article:10823419 | pubmed:abstractText | We injected cyclophosphamide into mice and examined their natural killer (NK) activity both in vitro and in vivo. Cyclophosphamide injection temporarily abrogated the lung clearance activity of Yac-1 lymphoma cells, which is considered to be an index of NK activity in vivo. However, administration of recombinant human macrophage-colony-stimulating-factor (rhM-CSF) to cyclophosphamide-injected mice restored the lung clearance activity. To clarify whether the administration of rhM-CSF activated NK cells, we purified NK1.1+ cells from mice treated with cyclophosphamide and/or rhM-CSF and examined their functions (cytotoxicity, proliferation, and interferon gamma production) in vitro. Cyclophosphamide injection decreased the number, but did not suppress the functions of NK1.1+ cells. The numbers of NK1.1+ cells in cyclophosphamide-injected mice restored by rhM-CSF administration. And the functions of NK1.1+ cells from both saline-injected and cyclophosphamide-injected mice were accelerated by rhM-CSF administration. These results suggested that the temporary abrogation of NK activity in vivo caused by cyclophosphamide injection was due to a decrease in the number and not to suppression of the functions of NK1.1+ cells. The injection of cyclophosphamide into mice increased the number of tumor (B16 melanoma) nodules formed in the lungs and liver. However, treatment with rhM-CSF recovered the anti-metastatic activity in the lungs of cyclophosphamide-injected mice. These results show that administration of rhM-CSF restores NK activity suppressed by cyclophosphamide injection in vivo. | lld:pubmed |
| pubmed-article:10823419 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10823419 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823419 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10823419 | pubmed:month | May | lld:pubmed |
| pubmed-article:10823419 | pubmed:issn | 0340-7004 | lld:pubmed |
| pubmed-article:10823419 | pubmed:author | pubmed-author:SakuraiTT | lld:pubmed |
| pubmed-article:10823419 | pubmed:author | pubmed-author:YamadaMM | lld:pubmed |
| pubmed-article:10823419 | pubmed:author | pubmed-author:MotoyoshiKK | lld:pubmed |
| pubmed-article:10823419 | pubmed:author | pubmed-author:HayasawaHH | lld:pubmed |
| pubmed-article:10823419 | pubmed:author | pubmed-author:MisawaEE | lld:pubmed |
| pubmed-article:10823419 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10823419 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:10823419 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10823419 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10823419 | pubmed:pagination | 94-100 | lld:pubmed |
| pubmed-article:10823419 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10823419 | pubmed:meshHeading | pubmed-meshheading:10823419... | lld:pubmed |
| pubmed-article:10823419 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10823419 | pubmed:articleTitle | Effects of macrophage-colony-stimulating factor on cyclophosphamide-injected mouse NK1.1+ cell activity. | lld:pubmed |
| pubmed-article:10823419 | pubmed:affiliation | Biochemical Research Laboratory, Morinaga Milk Industry Co. Ltd., Zama City, Kanagawa pref., Japan. | lld:pubmed |
| pubmed-article:10823419 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10823419 | lld:pubmed |
