| pubmed-article:10822379 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10822379 | lifeskim:mentions | umls-concept:C0014239 | lld:lifeskim |
| pubmed-article:10822379 | lifeskim:mentions | umls-concept:C0026237 | lld:lifeskim |
| pubmed-article:10822379 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:10822379 | lifeskim:mentions | umls-concept:C0332298 | lld:lifeskim |
| pubmed-article:10822379 | lifeskim:mentions | umls-concept:C1516044 | lld:lifeskim |
| pubmed-article:10822379 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:10822379 | pubmed:dateCreated | 2000-6-7 | lld:pubmed |
| pubmed-article:10822379 | pubmed:abstractText | Apoptosis involves mitochondrial steps such as the release of the apoptogenic factor cytochrome c which are effectively blocked by Bcl-2. Although Bcl-2 may have a direct action on the mitochondrial membrane, it also resides and functions on the endoplasmic reticulum (ER), and there is increasing evidence for a role of the ER in apoptosis regulation as well. Here we uncover a hitherto unrecognized, apoptotic crosstalk between the ER and mitochondria that is controlled by Bcl-2. After triggering massive ER dilation due to an inhibition of secretion, the drug brefeldin A (BFA) induces the release of cytochrome c from mitochondria in a caspase-8- and Bid-independent manner. This is followed by caspase-3 activation and DNA/nuclear fragmentation. Surprisingly, cytochrome c release by BFA is not only blocked by wild-type Bcl-2 but also by a Bcl-2 variant that is exclusively targeted to the ER (Bcl-2/cb5). Similar findings were obtained with tunicamycin, an agent interfering with N-linked glycosylations in the secretory system. Thus, apoptotic agents perturbing ER functions induce a novel crosstalk between the ER and mitochondria that can be interrupted by ER-based Bcl-2. | lld:pubmed |
| pubmed-article:10822379 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10822379 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10822379 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10822379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10822379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10822379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10822379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10822379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10822379 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10822379 | pubmed:month | May | lld:pubmed |
| pubmed-article:10822379 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:10822379 | pubmed:author | pubmed-author:BornerCC | lld:pubmed |
| pubmed-article:10822379 | pubmed:author | pubmed-author:EggerLL | lld:pubmed |
| pubmed-article:10822379 | pubmed:author | pubmed-author:MonneyLL | lld:pubmed |
| pubmed-article:10822379 | pubmed:author | pubmed-author:FellayII | lld:pubmed |
| pubmed-article:10822379 | pubmed:author | pubmed-author:RosséTT | lld:pubmed |
| pubmed-article:10822379 | pubmed:author | pubmed-author:ConusSS | lld:pubmed |
| pubmed-article:10822379 | pubmed:author | pubmed-author:HäckiJJ | lld:pubmed |
| pubmed-article:10822379 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10822379 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:10822379 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:10822379 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10822379 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10822379 | pubmed:pagination | 2286-95 | lld:pubmed |
| pubmed-article:10822379 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10822379 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10822379 | pubmed:articleTitle | Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2. | lld:pubmed |
| pubmed-article:10822379 | pubmed:affiliation | Institute of Biochemistry, University of Fribourg, Switzerland. | lld:pubmed |
| pubmed-article:10822379 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10822379 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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