| pubmed-article:10821785 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10821785 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:10821785 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:10821785 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:10821785 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:10821785 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:10821785 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:10821785 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:10821785 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:10821785 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10821785 | pubmed:dateCreated | 2000-8-1 | lld:pubmed |
| pubmed-article:10821785 | pubmed:abstractText | Nitric oxide (NO) modulates the levels of various neurotransmitters in the CNS. Here we determined whether the specific nitric oxide synthase (NOS) inhibitor 7-nitroindazole (7-NI), the non-selective inhibitor of guanylate cyclase (GC) and NOS, methylene blue (MB), the NO-precursor L-arginine (L-Arg), and the selective soluble GC inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) affect extracellular levels of serotonin (5-HT), dopamine (DA), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA) in the rat ventral hippocampus by using microdialysis in freely moving animals. Local perfusion of 7-NI (1 mM) and MB (1 mM) significantly increased extracellular level of 5-HT, whereas DA was increased by 7-NI only. Systemic administration of 7-NI (50 mg kg(-1)) and MB (30 mg kg(-1)) increased the extracellular levels of 5-HT and DA. Extracellular levels of 5-HIAA was not influenced by local or systemic MB or 7-NI. In contrast, extracellular level of HVA was decreased by systemic MB and retrodialyzed MB, but was not influenced by 7-NI. Retrodialysis of L-Arg (2 mM) decreased the levels of 5-HT, DA, 5-HIAA and HVA in the hippocampus. Systemic administration of L-Arg (250 mg kg(-1)) decreased the level of 5-HT, but failed to influence DA, 5-HIAA and HVA. Local perfusion of ODQ (400 microM) did not affect 5-HT overflow in the hippocampus. We conclude that NOS inhibitors increased extracellular levels of 5-HT and DA in the rat ventral hippocampus after local or systemic administration, whereas the NO precursor L-Arg had the opposite effect. Thus, endogenous NO may exert a negative control over the levels of 5-HT and DA in the hippocampus. However, this effect is probably not mediated by cyclic GMP. | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10821785 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10821785 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10821785 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10821785 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:10821785 | pubmed:author | pubmed-author:RosenbergRR | lld:pubmed |
| pubmed-article:10821785 | pubmed:author | pubmed-author:WegenerGG | lld:pubmed |
| pubmed-article:10821785 | pubmed:author | pubmed-author:VolkeVV | lld:pubmed |
| pubmed-article:10821785 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10821785 | pubmed:volume | 130 | lld:pubmed |
| pubmed-article:10821785 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10821785 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10821785 | pubmed:pagination | 575-80 | lld:pubmed |
| pubmed-article:10821785 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:meshHeading | pubmed-meshheading:10821785... | lld:pubmed |
| pubmed-article:10821785 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10821785 | pubmed:articleTitle | Endogenous nitric oxide decreases hippocampal levels of serotonin and dopamine in vivo. | lld:pubmed |
| pubmed-article:10821785 | pubmed:affiliation | Department of Biological Psychiatry, Institute for Basic Psychiatric Research, Skovagervej 2, DK-8240 Risskov, Denmark. wegener@dadlnet.dk | lld:pubmed |
| pubmed-article:10821785 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10821785 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10821785 | lld:pubmed |
