| pubmed-article:10820130 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10820130 | lifeskim:mentions | umls-concept:C0033572 | lld:lifeskim |
| pubmed-article:10820130 | lifeskim:mentions | umls-concept:C0008663 | lld:lifeskim |
| pubmed-article:10820130 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:10820130 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:10820130 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10820130 | pubmed:dateCreated | 2000-8-7 | lld:pubmed |
| pubmed-article:10820130 | pubmed:abstractText | Recent studies suggest that hereditary prostate cancer is a complex disease involving multiple susceptibility genes and variable phenotypic expression. While conducting a genomewide search on 162 North American families with > or =3 members affected with prostate cancer (PRCA), we found evidence for linkage to chromosome 20q13 with two-point parametric LOD scores >1 at multiple sites, with the highest two-point LOD score of 2.69 for marker D20S196. The maximum multipoint NPL score for the entire data set was 3.02 (P=.002) at D20S887. On the basis of findings from previous reports, families were stratified by the presence (n=116) or absence (n=46) of male-to-male transmission, average age of diagnosis (<66 years, n=73; > or =66 years, n=89), and number of affected individuals (<5, n=101; > or =5, n=61) for further analysis. The strongest evidence of linkage was evident with the pedigrees having <5 family members affected with prostate cancer (multipoint NPL 3.22, P=.00079), a later average age of diagnosis (multipoint NPL 3.40, P=.0006), and no male-to-male transmission (multipoint NPL 3.94, P=.00007). The group of patients having all three of these characteristics (n=19) had a multipoint NPL score of 3.69 (P=.0001). These results demonstrate evidence for a PRCA susceptibility locus in a subset of families that is distinct from the groups more likely to be linked to previously identified loci. | lld:pubmed |
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| pubmed-article:10820130 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10820130 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10820130 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10820130 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10820130 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10820130 | pubmed:issn | 0002-9297 | lld:pubmed |
| pubmed-article:10820130 | pubmed:author | pubmed-author:FrenchA JAJ | lld:pubmed |
| pubmed-article:10820130 | pubmed:author | pubmed-author:BerryRR | lld:pubmed |
| pubmed-article:10820130 | pubmed:author | pubmed-author:ThibodeauS... | lld:pubmed |
| pubmed-article:10820130 | pubmed:author | pubmed-author:SchroederJ... | lld:pubmed |
| pubmed-article:10820130 | pubmed:author | pubmed-author:PetersonB JBJ | lld:pubmed |
| pubmed-article:10820130 | pubmed:author | pubmed-author:SchaidD JDJ | lld:pubmed |
| pubmed-article:10820130 | pubmed:author | pubmed-author:CunninghamJ... | lld:pubmed |
| pubmed-article:10820130 | pubmed:author | pubmed-author:McDonnellS... | lld:pubmed |
| pubmed-article:10820130 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10820130 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:10820130 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10820130 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10820130 | pubmed:pagination | 82-91 | lld:pubmed |
| pubmed-article:10820130 | pubmed:dateRevised | 2010-9-14 | lld:pubmed |
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| pubmed-article:10820130 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10820130 | pubmed:articleTitle | Evidence for a prostate cancer-susceptibility locus on chromosome 20. | lld:pubmed |
| pubmed-article:10820130 | pubmed:affiliation | Department of Laboratory Medicine and Pathology, Mayo Clinic/Foundation, Rochester, MN 55905, USA. | lld:pubmed |
| pubmed-article:10820130 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10820130 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10820130 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:408259 | entrezgene:pubmed | pubmed-article:10820130 | lld:entrezgene |
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