A role for P-glycoprotein in regulating cell death.

Source:http://linkedlifedata.com/resource/pubmed/id/10811443

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Authors

Smyth MJ, Johnstone RW, Ruefli AA, Tainton KM

Affiliation

Cellular Cytotoxicity Laboratory, The Austin Research Institute, Australia, Victoria. r.johnstone@ari.unimelb.edu.au

Abstract

P-glycoprotein (P-gp) is an energy dependent drug pump responsible for multidrug resistance (MDR) in human cancers. While it is irrefutable that P-gp can efflux xenobiotics out of cells, the biological function of P-gp in multicellular organisms has yet to be firmly established. The question of what, if anything, P-gp does when not effluxing drugs has been raised by recent reports indicating that P-gp may regulate apoptosis, chloride channel activity, cholesterol metabolism and immune cell function. There is now a lively debate regarding the possible role of P-gp in regulating cell differentiation, proliferation and survival.

PMID
10811443

Publication types

Review; Research Support, Non-U.S. Gov't

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