| pubmed-article:10810988 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10810988 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:10810988 | lifeskim:mentions | umls-concept:C1458155 | lld:lifeskim |
| pubmed-article:10810988 | lifeskim:mentions | umls-concept:C0665341 | lld:lifeskim |
| pubmed-article:10810988 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:10810988 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:10810988 | lifeskim:mentions | umls-concept:C1521733 | lld:lifeskim |
| pubmed-article:10810988 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:10810988 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:10810988 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:10810988 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:10810988 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10810988 | pubmed:dateCreated | 2000-7-19 | lld:pubmed |
| pubmed-article:10810988 | pubmed:abstractText | Eighty-nine canine mammary tumors and dysplasias of 66 bitches were investigated to determine the immunohistochemical expression of classical estrogen receptor (ER-alpha) and its clinical and pathologic associations and prognostic value. A complete clinical examination was performed and reproductive history was evaluated. After surgery, all animals were followed-up for 18 months, with clinical examinations every 3-4 months. ER-alpha expression was higher in tumors of genitally intact and young bitches (P < 0.01, P < 0.01) and in animals with regular estrous periods (P = 0.03). Malignant tumors of the bitches with a previous clinical history of pseudopregnancy expressed significantly more ER-alpha (P = 0.04). Immunoexpression of ER-alpha decreased significantly with tumor size (P = 0.05) and skin ulceration (P = 0.01). Low levels of ER-alpha were significantly associated with lymph node involvement (P < 0.01). Malignant tumors had lower ER-alpha expression than did benign tumors (P < 0.01). Proliferation index measured by proliferating cell nuclear antigen immunostaining was inversely correlated with ER-alpha scores (P = 0.05) in all tumors. Low ER-alpha levels in primary malignant tumors were significantly associated with the occurrence of metastases in the follow-up (P = 0.03). Multivariate analyses were performed to determine the prognostic significance of some follow-up variables. ER-alpha value, Ki-67 index, and age were independent factors that could predict disease-free survival. Lymph node status, age, and ER-alpha index were independent prognostic factors for the overall survival. The immunohistochemical detection of ER-alpha in canine mammary tumors is a simple technique with prognostic value that could be useful in selecting appropriate hormonal therapy. | lld:pubmed |
| pubmed-article:10810988 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10810988 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10810988 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10810988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10810988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10810988 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10810988 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10810988 | pubmed:month | May | lld:pubmed |
| pubmed-article:10810988 | pubmed:issn | 0300-9858 | lld:pubmed |
| pubmed-article:10810988 | pubmed:author | pubmed-author:NietoAA | lld:pubmed |
| pubmed-article:10810988 | pubmed:author | pubmed-author:PeñaLL | lld:pubmed |
| pubmed-article:10810988 | pubmed:author | pubmed-author:CastañoMM | lld:pubmed |
| pubmed-article:10810988 | pubmed:author | pubmed-author:SánchezM AMA | lld:pubmed |
| pubmed-article:10810988 | pubmed:author | pubmed-author:FloresJ MJM | lld:pubmed |
| pubmed-article:10810988 | pubmed:author | pubmed-author:Pérez-AlenzaM... | lld:pubmed |
| pubmed-article:10810988 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10810988 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:10810988 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10810988 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10810988 | pubmed:pagination | 239-47 | lld:pubmed |
| pubmed-article:10810988 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10810988 | pubmed:meshHeading | pubmed-meshheading:10810988... | lld:pubmed |
| pubmed-article:10810988 | pubmed:meshHeading | pubmed-meshheading:10810988... | lld:pubmed |
| pubmed-article:10810988 | pubmed:meshHeading | pubmed-meshheading:10810988... | lld:pubmed |
| pubmed-article:10810988 | pubmed:meshHeading | pubmed-meshheading:10810988... | lld:pubmed |
| pubmed-article:10810988 | pubmed:meshHeading | pubmed-meshheading:10810988... | lld:pubmed |
| pubmed-article:10810988 | pubmed:meshHeading | pubmed-meshheading:10810988... | lld:pubmed |
| pubmed-article:10810988 | pubmed:meshHeading | pubmed-meshheading:10810988... | lld:pubmed |
| pubmed-article:10810988 | pubmed:meshHeading | pubmed-meshheading:10810988... | lld:pubmed |
| pubmed-article:10810988 | pubmed:meshHeading | pubmed-meshheading:10810988... | lld:pubmed |
| pubmed-article:10810988 | pubmed:meshHeading | pubmed-meshheading:10810988... | lld:pubmed |
| pubmed-article:10810988 | pubmed:meshHeading | pubmed-meshheading:10810988... | lld:pubmed |
| pubmed-article:10810988 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10810988 | pubmed:articleTitle | Immunohistologic detection of estrogen receptor alpha in canine mammary tumors: clinical and pathologic associations and prognostic significance. | lld:pubmed |
| pubmed-article:10810988 | pubmed:affiliation | Department of Animal Pathology II, Veterinary School, Universidad Complutense de Madrid, Spain. ananieto@eucmax.sim.ucm.es | lld:pubmed |
| pubmed-article:10810988 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10810988 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10810988 | lld:pubmed |
