| pubmed-article:10809019 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10809019 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:10809019 | lifeskim:mentions | umls-concept:C0030946 | lld:lifeskim |
| pubmed-article:10809019 | lifeskim:mentions | umls-concept:C0887947 | lld:lifeskim |
| pubmed-article:10809019 | lifeskim:mentions | umls-concept:C0121925 | lld:lifeskim |
| pubmed-article:10809019 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10809019 | pubmed:dateCreated | 2000-7-27 | lld:pubmed |
| pubmed-article:10809019 | pubmed:abstractText | The reduction in the efficacy of rescue treatment (administered on a clinical basis) due to drug resistance was retrospectively quantified in 55 human immunodeficiency virus type 1 (HIV-1)-infected patients failing highly active antiretroviral therapy (HAART) by using a novel score calculation system based upon HIV-1 reverse transcriptase (RT) and protease (PR) mutations. Patients were all naive for nelfinavir (NFV) and efavirenz (EFV) and were assigned to one of the following rescue therapy schedules: (i) 17 patients received NFV + EFV + stavudine (d4T) (group A); (ii) 14 patients received NFV + saquinavir (SQV) + lamivudine (3TC) + d4T/zidovudine (AZT) (group B); (iii) 19 patients received NFV + d4T + didanosine (ddI)/3TC/zalcitabine (ddC) (group C); (iv) five patients received miscellaneous treatments including NFV (group D). Responders were considered patients showing a drop in HIV-1 RNA level > 0.5 log10 after 3 months of therapy. Forty-eight (28 responders and 20 non-responders) out of 55 patients completed the first 3 months of rescue therapy and reduction in HIV-1 viral load was found to be significantly higher in group A compared to groups B and C (81.2% responders vs. 38.5 and 40.0%, respectively). At baseline, no patient carried EFV- or d4T-resistant HIV-1 strains, despite prolonged administration of d4T, while 41/48 (87.2%) patients had mutations conferring resistance to NFV in the absence of previous treatment with this drug. A significant inverse correlation between reduction in viral load and reduction in therapy efficacy due to drug resistance, as determined by the score calculation system, was found (r = 0.62). A cut-off value of 36% reduction in therapy efficacy showed a positive predictive value (capacity to detect failure of rescue treatment) of 81.2% and a negative predictive value (ability to detect successful treatment) of 75.8%. In addition, 45 out of 48 patients completed also the 9-12 month period of rescue therapy and 10/28 responders had a rebound in HIV-1 viral load level detected after the first 3 months of rescue therapy. Of these, 5/7 (71.4%) showed a further reduction in rescue therapy efficacy due to the emergence of new mutations. | lld:pubmed |
| pubmed-article:10809019 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10809019 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10809019 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10809019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10809019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10809019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10809019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10809019 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10809019 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10809019 | pubmed:issn | 0166-3542 | lld:pubmed |
| pubmed-article:10809019 | pubmed:author | pubmed-author:GernaGG | lld:pubmed |
| pubmed-article:10809019 | pubmed:author | pubmed-author:SuterFF | lld:pubmed |
| pubmed-article:10809019 | pubmed:author | pubmed-author:CastelliFF | lld:pubmed |
| pubmed-article:10809019 | pubmed:author | pubmed-author:MaseratiRR | lld:pubmed |
| pubmed-article:10809019 | pubmed:author | pubmed-author:BaldantiFF | lld:pubmed |
| pubmed-article:10809019 | pubmed:author | pubmed-author:PanAA | lld:pubmed |
| pubmed-article:10809019 | pubmed:author | pubmed-author:MaggioloFF | lld:pubmed |
| pubmed-article:10809019 | pubmed:author | pubmed-author:PaolucciSS | lld:pubmed |
| pubmed-article:10809019 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10809019 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:10809019 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10809019 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10809019 | pubmed:pagination | 101-14 | lld:pubmed |
| pubmed-article:10809019 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10809019 | pubmed:meshHeading | pubmed-meshheading:10809019... | lld:pubmed |
| pubmed-article:10809019 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10809019 | pubmed:articleTitle | Quantification of the impact of HIV-1 reverse transcriptase and protease mutations on the efficacy of rescue HAART. | lld:pubmed |
| pubmed-article:10809019 | pubmed:affiliation | Servizio di Virologia, IRCCS Policlinico S. Matteo, Pavia, Italy. | lld:pubmed |
| pubmed-article:10809019 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10809019 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10809019 | lld:pubmed |
