| pubmed-article:10802710 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10802710 | lifeskim:mentions | umls-concept:C0026649 | lld:lifeskim |
| pubmed-article:10802710 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10802710 | lifeskim:mentions | umls-concept:C0282554 | lld:lifeskim |
| pubmed-article:10802710 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:10802710 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10802710 | pubmed:dateCreated | 2000-5-25 | lld:pubmed |
| pubmed-article:10802710 | pubmed:abstractText | Movement towards or away from a given stimulus guides the directional migration of prokaryotes, simple eukaryotes and neurons. As bi-directional cues may influence entry and exit of immune effector cells from tissue sites, we evaluated the migratory responses of T-cell subsets to varying concentrations of the chemokine stromal cell derived factor-1 (SDF-1). There was selective repulsion of subpopulations of T cells at high concentrations of recombinant SDF-1 or naturally occurring bone marrow-derived SDF-1, which could be inhibited by pertussis toxin and antibody against the chemokine receptor CXCR4. Distinct sensitivity profiles to genistein, herbimycin and 8-Br-cAMP biochemically distinguished movement of cells towards or away from an SDF-1 gradient. In vivo, antigen-induced T-cell recruitment into the peritoneal cavity was reversed by high but not low concentrations of SDF-1. The phenomenon of movement away from a chemokine represents a previously unknown mechanism regulating the localization of mature T cells. It adds to the functional repertoire of chemokines that may participate in immune physiology and may be applied therapeutically to alter the immune response. | lld:pubmed |
| pubmed-article:10802710 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10802710 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10802710 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10802710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10802710 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10802710 | pubmed:month | May | lld:pubmed |
| pubmed-article:10802710 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:10802710 | pubmed:author | pubmed-author:EvansR HRH | lld:pubmed |
| pubmed-article:10802710 | pubmed:author | pubmed-author:ScaddenD TDT | lld:pubmed |
| pubmed-article:10802710 | pubmed:author | pubmed-author:PoznanskyM... | lld:pubmed |
| pubmed-article:10802710 | pubmed:author | pubmed-author:LusterA DAD | lld:pubmed |
| pubmed-article:10802710 | pubmed:author | pubmed-author:FoxallRR | lld:pubmed |
| pubmed-article:10802710 | pubmed:author | pubmed-author:OlszakI TIT | lld:pubmed |
| pubmed-article:10802710 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10802710 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:10802710 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10802710 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10802710 | pubmed:pagination | 543-8 | lld:pubmed |
| pubmed-article:10802710 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10802710 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10802710 | pubmed:articleTitle | Active movement of T cells away from a chemokine. | lld:pubmed |
| pubmed-article:10802710 | pubmed:affiliation | AIDS Research Center and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachussetts 02129, USA. | lld:pubmed |
| pubmed-article:10802710 | pubmed:publicationType | Journal Article | lld:pubmed |
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